Hemopexin and α1-microglobulin heme scavengers with differential involvement in preeclampsia and fetal growth restriction

• Published in: PloS one 2020-09, Vol.15 (9), p.e0239030-e0239030
• Main Authors: Youssef, Lina, Erlandsson, Lena, Åkerström, Bo, Miranda, Jezid, Paules, Cristina, Crovetto, Francesca, Crispi, Fatima, Gratacos, Eduard, Hansson, Stefan R.
• Format: Article
• Language: English
• Subjects: Biology and Life Sciences; Biomedical research; Blood; Blood pressure; Clinical Medicine; Cord blood; Creatinine; Disorders; Fetuses; Funding; Gene expression; Gestational age; Gynecology; Heme; Hemoglobin; Hemopexin; Hospitals; Hypoxia; Infections; Intensive care; Klinisk medicin; Medical and Health Sciences; Medicin och hälsovetenskap; Medicine; Medicine and Health Sciences; Mortality; Obstetrics; Obstetrics, Gynecology and Reproductive Medicine; Oxidative stress; Phenotypes; Placenta; Pre-eclampsia; Preeclampsia; Pregnancy; Reproduktionsmedicin och gynekologi; Scavengers; Ultrasonic imaging; Veins & arteries
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0239030

Hemopexin and α1-microglobulin act as scavengers to eliminate free heme-groups responsible for hemoglobin-induced oxidative stress. The present study evaluated maternal and fetal plasma concentrations of these scavengers in the different phenotypes of placenta-mediated disorders. Singleton pregnancies with normotensive fetal growth restriction [FGR] (n = 47), preeclampsia without FGR (n = 45) and preeclampsia with FGR (n = 51) were included prospectively as well as uncomplicated pregnancies (n = 49). Samples were collected at delivery and ELISA analysis was applied to measure the hemopexin and α1-microglobulin concentrations. In maternal blood in preeclampsia with and without FGR, hemopexin was significantly lower (p = 0.003 and p