Effect of Subthalamic Nucleus Deep Brain Stimulation (STN-DBS) on balance performance in Parkinson's disease

Purpose To study the effect of STN-DBS on balance performance of Parkinson's disease. Method 16 idiopathic PD patients treated with bilateral STN-DBS (DBS Group) and 20 PD patients treated with Levodopa (Medicine group) were included in the study. Clinical material including Levodopa Equivalent...

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Bibliographic Details
Published in:PloS one 2020-09, Vol.15 (9), p.e0238936-e0238936
Main Authors: Li, Haitao, Liang, Siquan, Yu, Yang, Wang, Yue, Cheng, Yuanyuan, Yang, Hechao, Tong, Xiaoguang, Witt, Karsten
Format: Article
Language:English
Subjects:
Balances (scales)
Biology and Life Sciences
Brain stimulation
Care and treatment
Causes of
Complications and side effects
Deep brain stimulation
Drug dosages
Electrical stimuli
Levodopa
Medicine
Medicine and Health Sciences
Motor task performance
Movement disorders
Neurodegenerative diseases
Neurosurgery
Parkinson disease
Parkinson's disease
Patient outcomes
Patients
Quality of life
Rehabilitation
Research and Analysis Methods
Solitary tract nucleus
Standard deviation
Subthalamic nucleus
Surgery
Target acquisition
Variance analysis
Vertigo
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Summary:Purpose To study the effect of STN-DBS on balance performance of Parkinson's disease. Method 16 idiopathic PD patients treated with bilateral STN-DBS (DBS Group) and 20 PD patients treated with Levodopa (Medicine group) were included in the study. Clinical material including Levodopa Equivalent Daily Dose (LEDD, mg/day), life quality (PDQ-39) were collected. For DBS group and Medicine group, The motor disability (Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale â¢, MDS-UPDRSIII) and balance performance (MDS-UPDRS 3.12, Berg Balance Scale BBS) and the Limits of Stability (LoS) (target acquisition percentage, trunk swing angle standard deviation, time) in state of Med-Off/Med-On at preoperation, postoperation, 6 months postoperation and 12 months postoperation were evaluated. Repeated ANOVA was used to analyze the effect of STN-DBS on balance performance. Result The Clinical material (age, gender, duration, LEDD preoperation, PDQ39), motor disability (Med-on/Med-Off), balance performance (Med-on/Med-Off) and LoS preoperation had no differences in DBS-group and Medical-group (P>0.05). During the follow up, LEDD, PDQ39, Motor disability (MDS-UPDRSIII), balance performance (MDS-UPDRS 3.12, BBS) in Medicine-group had no significant changes in both Med-Off and Med-On. For DBS-group, immediately improvement of motor disability (MDS-UPDRSIII), LoS (target acquisition percentage, trunk swing angle standard deviation, time) and LEDD were observed postoperation (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0238936