Studies of rice Hd1 haplotypes worldwide reveal adaptation of flowering time to different environments

• Published in: PloS one 2020-09, Vol.15 (9), p.e0239028-e0239028
• Main Authors: Wu, Cheng-Chieh, Wei, Fu-Jin, Chiou, Wan-Yi, Tsai, Yuan-Ching, Wu, Hshin-Ping, Gotarkar, Dhananjay, Wei, Zhi-Han, Lai, Ming-Hsin, Hsing, Yue-Ie Caroline
• Format: Article
• Language: English
• Subjects: Adaptation; Adaptation, Physiological - genetics; Alleles; Base Sequence - genetics; Biology; Biology and Life Sciences; Chromosome Mapping - methods; Computer and Information Sciences; Cultivation; Data mining; Domestication; Flowering; Flowers - genetics; Gene Frequency - genetics; Gene sequencing; Genes; Genes, Plant - genetics; Genetic aspects; Genetic engineering; Genetic Variation - genetics; Genomes; Genomics; Grain cultivation; Haplotypes; Haplotypes - genetics; Mutation; Oryza - genetics; People and Places; Phenotype; Phenotypes; Phylogeny; Physiological aspects; Plant acclimatization; Plant flowering; Plant Proteins - genetics; Population genetics; Proteins; Public domain; Research and Analysis Methods; Rice; Tropical environment; Tropical environments
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0239028

Rice domestication/adaptation is a good model for studies of the development and spread of this important crop. Mutations that caused morphological and physiological change, followed by human selection/expansion, finally led to the improvement of phenotypes suitable for different kinds of environments. We used the sequence information for Heading date 1 (Hd1) gene to reveal the association between sequence changes and flowering phenotypes of rice in different regions. Seven loss-of-function hd1 haplotypes had been reported. By data-mining the genome sequencing information in the public domain, we discovered 3 other types. These loss-of-function allele haplotypes are present in subtropical and tropical regions, which indicates human selection. Some of these haplotypes are present locally. However, types 7 and 13 are present in more than one-third of the world's rice accessions, including landraces and modern varieties. In the present study, phylogenetic, allele network and selection pressure analyses revealed that these two haplotypes might have occurred early in Southeastern Asia and then were introgressed in many local landraces in nearby regions. We also demonstrate that these haplotypes are present in weedy rice populations, which again indicates that these alleles were present in rice cultivation for long time. In comparing the wild rice sequence information, these loss-of-function haplotypes occurred in agro but were not from wild rice.