Cerebral hemodynamics in stroke thrombolysis (CHiST) study

Despite careful patient selection, successful recanalization in intravenous thrombolysis is only achieved in approximately 50% of cases. Understanding changes in cerebral autoregulation during and following successful recanalization in acute ischemic stroke patients who receive intravenous thromboly...

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Bibliographic Details
Published in:PloS one 2020-09, Vol.15 (9), p.e0238620
Main Authors: Lam, Man Y, Haunton, Victoria J, Panerai, Ronney B, Robinson, Thompson G
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Anticoagulants
Biology and Life Sciences
Biomedical research
Blood pressure
Blood Pressure - physiology
Brain - physiopathology
Capnography
Carbon dioxide
Carbon Dioxide - metabolism
Care and treatment
Cerebral circulation
Electrocardiography
Female
Health aspects
Health risks
Heart rate
Heart Rate - physiology
Hemodynamics
Hemodynamics - physiology
Homeostasis
Humans
Injury prevention
Intravenous administration
Ischemia
Male
Medical research
Medicine and Health Sciences
Middle Aged
Noise
Physiological aspects
Reperfusion
Risk reduction
Stroke
Stroke - physiopathology
Stroke - therapy
Supervision
Thrombolysis
Thrombolytic Therapy
Time Factors
Ultrasonic imaging
Ultrasound
Veins & arteries
Velocity
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Summary:Despite careful patient selection, successful recanalization in intravenous thrombolysis is only achieved in approximately 50% of cases. Understanding changes in cerebral autoregulation during and following successful recanalization in acute ischemic stroke patients who receive intravenous thrombolysis, may inform the management of common physiological perturbations, including blood pressure, in turn reducing the risk of reperfusion injury. Cerebral blood velocity (Transcranial Doppler), blood pressure (Finometer) and end-tidal carbon dioxide (capnography) were continuously recorded in 11 acute ischemic stroke patients who received intravenous thrombolysis (5 female, mean ± SD age 68±12 years) over 4-time points, during and at the following time intervals after intravenous thrombolysis: 23.9±2.6 hrs, 18.1±7.0 days and 89.6±4.2 days. Reductions in blood pressure (p = 0.04) were observed during intravenous thrombolysis. Reductions in heart rate (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0238620