Circulating levels of microRNA193a-5p predict outcome in early stage hepatocellular carcinoma

While tumor resection and liver transplantation (LT) represent potentially curative therapeutic options for patients with early-stage hepatocellular carcinoma (HCC), the identification of the ideal surgical candidates has remained challenging. Just recently, miRNA-193a-5p was described as a tumor su...

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Bibliographic Details
Published in:PloS one 2020-09, Vol.15 (9), p.e0239386
Main Authors: Loosen, Sven H, Wirtz, Theresa H, Roy, Sanchari, Vucur, Mihael, Castoldi, Mirco, Schneider, Anne T, Koppe, Christiane, Ulmer, Tom F, Roeth, Anjali A, Bednarsch, Jan, Alizai, Patrick H, Paffenholz, Pia, Demir, Münevver, Trautwein, Christian, Tacke, Frank, Neumann, Ulf P, Roderburg, Christoph, Luedde, Tom
Format: Article
Language:English
Subjects:
Biology and life sciences
Biomarkers
Blood & organ donations
Etiology
Gastroenterology
Gene expression
Genetic aspects
Health aspects
Hepatocellular carcinoma
Hepatology
Hospitals
Infectious diseases
Kidney cancer
Liver cancer
Liver transplantation
Liver transplants
Medicine
Medicine and Health Sciences
MicroRNA
miRNA
Oncology
Patient outcomes
Patients
Prognosis
Regression analysis
Serum levels
Surgery
Surgical outcomes
Transplantation
Tumor suppressor genes
Tumors
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Summary:While tumor resection and liver transplantation (LT) represent potentially curative therapeutic options for patients with early-stage hepatocellular carcinoma (HCC), the identification of the ideal surgical candidates has remained challenging. Just recently, miRNA-193a-5p was described as a tumor suppressor in murine and human HCC but only little is known about circulating miRNA-193a-5p in HCC patients. Here, we evaluated serum levels of miR-193a-5p by qPCR in 41 HCC patients undergoing tumor resection (n = 33) or LT (n = 8) and 20 controls. Circulating relative miR-193a-5p levels were significantly elevated in HCC patients compared to healthy controls. While relative miR-193a-5p levels were comparable between patients of different underlying disease etiology and tumor size, high relative miR-193a-5p levels were predictive for the patients' postoperative outcome, which was confirmed in uni- and multivariate Cox-regression analysis. As such, HCC patients with a preoperative relative miR-193a-5p level above the ideal cut-off value (3.57) had a median overall survival (OS) of only 451 days compared to 1158 days in patients with a relative miR-193a-5p level below this cut-off value. Our data support a novel function of miR-193a-5p as a biomarker in early-stage HCC patients that might help to identify the best surgical candidates in terms of postoperative outcome.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0239386