Low pectoralis muscle index, cavitary nodule or mass and segmental to lobar consolidation as predictors of primary multidrug-resistant tuberculosis: A comparison with primary drug sensitive tuberculosis

The loss of muscle mass in primary multidrug-resistant tuberculosis (MDR-TB) has not been examined in previous studies. This study aimed to investigate that low pectoralis muscle index and characteristic CT features can help differentiate patients with primary MDR-TB from those with drug-sensitive t...

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Bibliographic Details
Published in:PloS one 2020-10, Vol.15 (10), p.e0239431-e0239431
Main Authors: Shin, Hwa Seon, Choi, Dae Seob, Na, Jae Boem, Choi, Hye Young, Kim, Ji-Eun, Choi, Ho Cheol, Won, Jung Ho, Lee, Seung Jun, Park, Mi Jung
Format: Article
Language:English
Subjects:
Age
Biology and Life Sciences
Body composition
Body mass
Body mass index
Body size
Computed tomography
Confidence intervals
Consolidation
Diagnosis
Drug resistance
Histograms
Hospitals
Infections
Lung diseases
Lymphatic system
Malnutrition
Medical diagnosis
Medicine
Medicine and Health Sciences
Multidrug resistance
Multidrug resistant organisms
Muscles
Muscular atrophy
Nodules
Patients
Regression analysis
Research and Analysis Methods
Statistical analysis
Tuberculosis
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Summary:The loss of muscle mass in primary multidrug-resistant tuberculosis (MDR-TB) has not been examined in previous studies. This study aimed to investigate that low pectoralis muscle index and characteristic CT features can help differentiate patients with primary MDR-TB from those with drug-sensitive tuberculosis (DS-TB). From 2010 to 2016, we retrospectively enrolled 90 patients with primary MDR-TB and 90 age- and sex-matched patients with primary DS-TB. The pectoralis muscle mass was quantitatively measured on axial CT images using density histogram analysis. The pectoralis muscle index (PMI) was defined as the pectoralis muscle mass divided by body mass index. We compared the PMI and characteristic CT features of pulmonary tuberculosis between the two groups. Low PMI, segmental to lobar consolidation, cavity in consolidation, cavitary nodule or mass, and bilateral involvement were more frequently observed in patients with MDR-TB than in those with DS-TB. In stepwise multivariate logistic regression analysis, low PMI (odds ratio, 2.776; 95% confidence interval, 1.450-5.314; p = 0.002), segmental or lobar consolidation (odds ratio, 3.123; 95% confidence interval, 1.629-5.987; p = 0.001), and cavitary nodule or mass (odds ratio, 2.790; 95% confidence interval, 1.348-5.176; p = 0.002) were significant factors for MDR-TB. Low pectoralis muscle index, segmental to lobar consolidation and cavitary nodule or mass can help differentiate primary MDR-TB from DS-TB.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0239431