Serum kynurenine levels are a novel biomarker to predict the prognosis of patients with hepatocellular carcinoma

We examined serum kynurenine levels in patients with chronic hepatitis C virus infection, and the relationship between serum kynurenine and prognosis in patients with hepatocellular carcinoma (HCC) and chronic hepatitis C. We retrospectively analyzed 604 patients with HCC diagnosed between January 1...

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Bibliographic Details
Published in:PloS one 2020-10, Vol.15 (10), p.e0241002-e0241002
Main Authors: Bekki, Shigemune, Hashimoto, Satoru, Yamasaki, Kazumi, Komori, Atsumasa, Abiru, Seigo, Nagaoka, Shinya, Saeki, Akira, Suehiro, Tomoyuki, Kugiyama, Yuki, Beppu, Asami, Kuroki, Tamotsu, Nakamura, Minoru, Ito, Masahiro, Yatsuhashi, Hiroshi
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological markers
Biology and Life Sciences
Biomarkers
Biomarkers, Tumor - blood
Breast cancer
Carcinoma, Hepatocellular - blood
Carcinoma, Hepatocellular - mortality
Carcinoma, Hepatocellular - virology
Chronic infection
Consent
Drug development
Ethics
Female
Health aspects
Health care facilities
Hepatitis
Hepatitis C
Hepatitis C, Chronic - blood
Hepatitis C, Chronic - complications
Hepatocellular carcinoma
Hospitals
Humans
Infections
Kaplan-Meier Estimate
Kynurenine - blood
Liver cancer
Liver diseases
Liver Neoplasms - blood
Liver Neoplasms - mortality
Liver Neoplasms - virology
Male
Medical imaging
Medical prognosis
Medical records
Medical screening
Medicine and Health Sciences
Mental depression
Metabolites
Middle Aged
Multivariate analysis
Patients
Physiological aspects
Prognosis
Rank tests
Regression analysis
Retrospective Studies
Statistical analysis
Supervision
Survival
Survival Rate
University graduates
Viruses
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Description
Summary:We examined serum kynurenine levels in patients with chronic hepatitis C virus infection, and the relationship between serum kynurenine and prognosis in patients with hepatocellular carcinoma (HCC) and chronic hepatitis C. We retrospectively analyzed 604 patients with HCC diagnosed between January 1999 and December 2015, and 288 patients without HCC who were seen at the National Hospital Organization Nagasaki Medical Center between October 2014 and November 2017. The association between serum kynurenine and prognosis was evaluated using the Cox's proportional hazards regression analysis. Patients with HCC had significantly higher values of serum kynurenine than patients without HCC (median: 557.1 vs. 464.2 ng/mL, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0241002