Effects of high intensity interval training on neuro-cardiovascular dynamic changes and mitochondrial dysfunction induced by high-fat diet in rats

Mitochondrial swelling is involved in the pathogenesis of many human diseases associated with oxidative stress including obesity. One of the strategies for prevention of deleterious effects related to obesity and overweight is engaging in regular physical activity, of which high intensity interval t...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2020-10, Vol.15 (10), p.e0240060-e0240060
Main Authors: Marques Neto, Silvio R, Castiglione, Raquel C, da Silva, Teresa C. B, Paes, Lorena da S, Pontes, Aiza, Oliveira, Dahienne F, Ferraz, Emanuelle B, Ade Caldas, Carla Christina, Nascimento, José Hamilton M, Bouskela, Eliete
Format: Article
Language:English
Subjects:
Adipose tissue
Biology
Biology and Life Sciences
Biophysics
Blood pressure
Body weight
Brain
Capillary pressure
Cardiovascular diseases
Cardiovascular system
Density
Diet
Dynamic control
Exercise
Experimentation
Fasting
Fitness equipment
Glucose
Glucose tolerance
Health aspects
Heart
High fat diet
High intensity interval training
Hypertrophy
Insulin
Insulin resistance
Interval training
Laboratory animals
Laboratory testing
Medicine and Health Sciences
Metabolism
Mitochondria
Mitochondrial diseases
Nervous system
Obesity
Overweight
Oxidative stress
Parameters
Pathogenesis
Physical activity
Physical education
Physical fitness
Physiology
Prevention
Risk factors
Subgroups
Swelling
Training
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Mitochondrial swelling is involved in the pathogenesis of many human diseases associated with oxidative stress including obesity. One of the strategies for prevention of deleterious effects related to obesity and overweight is engaging in regular physical activity, of which high intensity interval training (HIIT) is efficient in promoting biogenesis and improving the function of mitochondria. Therefore, our aims were to investigate the effects of HIIT on metabolic and neuro-cardiovascular dynamic control and mitochondrial swelling induced by high-fat diet (HFD). Twenty-three male Wistar rats (60 - 80g) were divided into 4 subgroups: control (C), HIIT, HFD and HFD+HIIT. The whole experimentation period lasted for 22 weeks and HIIT sessions were performed 5 days a week during the last 4 weeks. At the end of the experiments, fasting glucose and insulin tolerance tests were performed. Cerebral microcirculation was analyzed using cortical intravital microscopy for capillary diameter and functional density. Cardiac function and ergoespirometric parameters were also investigated. Mitochondrial swelling was evaluated on brain and heart extracts. HFD promoted an increase on body adiposity (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0240060