The association of types, intensities and frequencies of physical activity with primary infertility among females in Gaza Strip, Palestine: A case-control study

• Published in: PloS one 2020-10, Vol.15 (10), p.e0241043
• Main Authors: Dhair, Amal, Abed, Yehia
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Age; Biology and Life Sciences; Capacity development; Case studies; Case-Control Studies; Couples; Energy; Energy expenditure; Exercise; Female; Female infertility; Females; Fertility; Follow-Up Studies; Health aspects; Health risks; Humans; Infertility; Infertility - epidemiology; Infertility - therapy; Medicine and Health Sciences; Menarche; Middle Aged; Middle East - epidemiology; Norms; People and Places; Physical activity; Physical fitness; Population; Pregnancy; Prognosis; Public health; Questionnaires; Refugees; Regression analysis; Reproduction; Reproductive health; Reproductive system; Reproductive systems; Retrospective Studies; Risk Factors; Sample size; Sampling techniques; Sedentary Behavior; Statistics; Surveys and Questionnaires; Tabulation; Young Adult
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0241043

Physical activity and energy state balance have fundamentally been related to reproductive system and health. This study explored the relationship between different types, intensities and frequencies of physical activity with primary infertility among women in Gaza Strip, Palestine. A case-control study was conducted in Gaza Strip with the participation of 320 married couples. 160 infertile couples were chosen from five fertility centers registries from 2016 to 2018 and matched residentially with 160 fertile couples. Cases were selected through systematic stratified sampling of five lists categorized according to residency and the determined percentage selected from each list was proportional. Data were collected through a self-administered questionnaire extended by the short form of international physical activity questionnaire and analyzed through SPSS program version 22 by using descriptive analysis, independent T-test, cross-tabulation, and binary logistic regression. Low frequency, intensity and duration of physical activity were associated with 3.1 risk of primary infertility (95% CI, 1.60-5.99, P < 0.001). Adjustment for age, marital age, age of menarche, refugee status and monthly income provided 3.2 risk (95% CI, 1.55-6.60, P = 0.002). Women spending more than 300 minutes a day sedentarily were 2.3 times more likely to have fertility problems than physically active females. Measuring energy expenditure in MET-min/w (Metabolic Equivalent) showed vigorous MET-min/w as negatively associated with the infertility status of females (Interquartile range IQR: 480 for cases and 720 for controls, P = 0.010). On the basis of energy expended in kilocalories in relation to weight, results showed the same association (IQR: 564 for case and 864 for controls, P = 0.011). No associations were found between moderate activity levels and primary infertility. Low levels of physical activity and sedentary lifestyle endanger the fertility status of females in Gaza Strip. This may offer the need for endorsing and formalizing adequate physical activity education and awareness protocols in the national reproductive health guidelines and empowering environmental capacity building to alter physical activity-related cultural norms.