COVID-19 gender susceptibility and outcomes: A systematic review

Epidemiological differences between men and women have been reported with regards to sepsis, influenza and severe coronavirus infections including SARS-CoV and MERS-CoV. To systematically review the literature relating to men versus women on SARS-CoV-2 in order to seek differences in disease charact...

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Bibliographic Details
Published in:PloS one 2020-11, Vol.15 (11), p.e0241827-e0241827
Main Authors: Lakbar, Ines, Luque-Paz, David, Mege, Jean-Louis, Einav, Sharon, Leone, Marc
Format: Article
Language:English
Subjects:
Adolescent sexuality
Betacoronavirus - isolation & purification
Biology and Life Sciences
Coronavirus Infections - diagnosis
Coronavirus Infections - mortality
Coronavirus Infections - pathology
Coronavirus Infections - virology
Coronaviruses
COVID-19
Demographic aspects
Disease Susceptibility
Epidemiology
Female
Health aspects
Hospitalization - statistics & numerical data
Humans
Infectivity
Influenza
Life Sciences
Literature reviews
Male
Medical research
Medicine and Health Sciences
Men
Middle East respiratory syndrome
Mortality
Odds Ratio
Pandemics
People and Places
Pneumonia, Viral - diagnosis
Pneumonia, Viral - mortality
Pneumonia, Viral - pathology
Pneumonia, Viral - virology
Public health
Research and Analysis Methods
Risk factors
SARS-CoV-2
Sepsis
Severe acute respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
Severity of Illness Index
Sex differences
Sex differences (Biology)
Sex Factors
Systematic review
Viral diseases
Women
Womens health
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Summary:Epidemiological differences between men and women have been reported with regards to sepsis, influenza and severe coronavirus infections including SARS-CoV and MERS-CoV. To systematically review the literature relating to men versus women on SARS-CoV-2 in order to seek differences in disease characteristics (e.g. infectivity, severity) and outcomes (e.g. mortality). We searched 3 electronic databases up or observational studies reporting differences between men and women in the SARS-CoV-2 disease characteristics stated. We identified and included 47 studies, reporting data for 21,454 patients mainly from China. The unadjusted mortality rates of men were higher than those of women, with a mortality OR 0.51 [0.42, 0.61] (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0241827