Lipopolysaccharide-induced innate immune responses are exacerbated by Prohibitin 1 deficiency and mitigated by S-adenosylmethionine in murine macrophages

Prohibitin 1 (Phb1) is a pleiotropic protein with multiple functions in mammalian cells including cell cycle regulation and mitochondrial protein stabilization. It has been proposed as a potential therapeutic target for a variety of diseases including inflammatory diseases. In this study, we investi...

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Bibliographic Details
Published in:PloS one 2020-11, Vol.15 (11), p.e0241224-e0241224
Main Authors: Jung, Soohan, Park, Jaehee, Ko, Kwang Suk
Format: Article
Language:English
Subjects:
Adenosylmethionine
Analysis
Animals
Anti-inflammatory agents
Antigens
Biology and Life Sciences
Causes of
Cell cycle
Cell Survival - drug effects
Chemical properties
Control
Cytokines
Cytokines - genetics
Cytokines - metabolism
Gene expression
IL-1β
Immune response
Immune system
Immunity, Innate - drug effects
Immunomodulation
Inflammation Mediators - metabolism
Inflammatory diseases
Inflammatory response
Influence
Innate immunity
Interleukin 1
Interleukin 10
Interleukin 6
Kinases
Lipopolysaccharides
Lipopolysaccharides - pharmacology
Lymphocytes B
Macrophages
Macrophages - drug effects
Macrophages - immunology
Mammalian cells
Medicine and Health Sciences
Mice
Mitochondria
NF-kappa B - metabolism
NF-κB protein
Nitric Oxide - biosynthesis
Nitric Oxide Synthase Type II - metabolism
Prohibitin
Protein deficiency
Protein expression
Proteins
RAW 264.7 Cells
Real time
Repressor Proteins - deficiency
Repressor Proteins - genetics
Repressor Proteins - metabolism
RNA, Messenger - genetics
RNA, Messenger - metabolism
S-Adenosylmethionine
S-Adenosylmethionine - pharmacology
Signal transduction
Statistical analysis
Tumor necrosis factor-TNF
Tumor necrosis factor-α
Variance analysis
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Summary:Prohibitin 1 (Phb1) is a pleiotropic protein with multiple functions in mammalian cells including cell cycle regulation and mitochondrial protein stabilization. It has been proposed as a potential therapeutic target for a variety of diseases including inflammatory diseases. In this study, we investigated the potential immune-modulatory functions of Phb1 and anti-inflammatory properties of S-adenosylmethionine (SAMe) using macrophages, which play a major role in the innate immune system. The results showed that expressions of Phb1 mRNA and protein were reduced in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0241224