Magnitude of first line antiretroviral therapy treatment failure and associated factors among adult patients on ART in South West Shoa, Central Ethiopia

First-line antiretroviral treatment failure has become a public health concern in high, low and middle-income countries with high mortality and morbidity In Ethiopia, around 710,000 peoples were living with HIV and 420,000 of them were receiving ART in 2017. Little is known about the magnitude of fi...

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Bibliographic Details
Published in:PloS one 2020-11, Vol.15 (11), p.e0241768-e0241768
Main Authors: Mulisa, Diriba, Tolossa, Tadesse, Wakuma, Bizuneh, Etafa, Werku, Yadesa, Girma
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
Adult
Adults
AIDS
Anti-Retroviral Agents - therapeutic use
Antiretroviral agents
Antiretroviral drugs
Antiretroviral therapy
Biology and Life Sciences
CD4 antigen
CD4 Lymphocyte Count
Clinics
Confidence intervals
Cross-Sectional Studies
Data collection
Dosage and administration
Drug resistance
Drug therapy
Ethiopia
Failure
Female
Health care facilities
Health facilities
Health sciences
Hemoglobin
HIV
HIV Infections - drug therapy
HIV patients
Hospital facilities
Human immunodeficiency virus
Humans
Immunology
Infections
Logistic Models
Male
Medicine and Health Sciences
Morbidity
Nevirapine
Nevirapine - therapeutic use
Odds Ratio
Opportunist infection
Patient outcomes
Patients
Pediatric nursing
People and Places
Public health
Random sampling
Regression analysis
Risk Factors
Sample size
Sampling techniques
Statistical analysis
Statistical sampling
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Summary:First-line antiretroviral treatment failure has become a public health concern in high, low and middle-income countries with high mortality and morbidity In Ethiopia, around 710,000 peoples were living with HIV and 420,000 of them were receiving ART in 2017. Little is known about the magnitude of first-line ART treatment failure and its associated factors in Ethiopia, particularly in the study area. Therefore, this study was aimed to find the magnitude of first-line ART treatment failure and its associated factors among adult patients attending ART clinic at Southwest shoa zone public hospitals. Institutions based cross-sectional study was employed from February 1 to April 2, 2019. An interviewer administered questionnaire was used to collect data from 350 adult patients on ART using a systematic random sampling technique. The collected data were coded and entered into Epidata version 3 and exported to STATA SE version 14 for analysis. Bivariable and multivariable logistic regression was done to identify factors associated with first-line ART treatment failure. At 95% confidence level strength of association was measured using Odds ratio. Variables with a p-value of ≤ 0.25 in the bivariable analysis were considered as a candidate variable for multivariable analysis. To get the final variables step-wise backward selection procedure was used and those in the final model were selected at a p-value
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0241768