Sex disparities in dialysis initiation, access to waitlist, transplantation and transplant outcome in German patients with renal disease-A population based analysis

• Published in: PloS one 2020-11, Vol.15 (11), p.e0241556-e0241556
• Main Authors: Melk, Anette, Schmidt, Bernhard M W, Geyer, Siegfried, Epping, Jelena
• Format: Article
• Language: English
• Subjects: Adult; Age; Age Factors; Aged; Aged, 80 and over; Analysis; Care and treatment; Chronic kidney failure; Datasets as Topic; Demographic aspects; Diabetes; Dialysis; Female; Female-male relations; Follow-Up Studies; Gender differences; Germany - epidemiology; Graft rejection; Graft Rejection - epidemiology; Graft Rejection - etiology; Grafts; Health aspects; Health care disparities; Health care services accessibility; Health insurance; Health risks; Health Services Accessibility - statistics & numerical data; Healthcare Disparities - statistics & numerical data; Hemodialysis; Humans; Incidence; Insurance coverage; Kidney diseases; Kidney Failure, Chronic - mortality; Kidney Failure, Chronic - therapy; Kidney transplantation; Kidney Transplantation - adverse effects; Kidney Transplantation - statistics & numerical data; Male; Medical treatment; Medicine and Health Sciences; Men; Middle Aged; Patient outcomes; Patients; Renal Dialysis - statistics & numerical data; Risk; Sex; Sex Factors; Socioeconomic factors; Statistical models; Transplantation; Treatment Outcome; Waiting Lists - mortality; Women
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0241556

Renal transplantation access and outcome differ between men and women, but no analysis has considered all transition phases and transplant outcome using the same data set. We analyzed sex disparities in all phases of patients' clinical path (progression to dialysis, waitlisting, transplantation, graft failure/death). In a population based approach using health insurance data (2005-2013) we examined patients' risk of changing from one phase to another applying Cox Proportional Hazards model. After adjusting for age and comorbidities, women had a 16% lower risk of progression to ESRD (HR/95%-CI: 0.84/0.79-0.88). Access to the waitlist was lowered by 18% in women compared to men (HR/95%-CI: 0.82/0.70-0.96). An age stratified analysis did not reveal differences in any age group. Once waitlisted, the chance to receive a transplant was identical (HR/95%-CI: 0.96/0.81-1.15). The risk of transplant failure/death was identical for both sexes (HR/95%-CI: 0.99/0.73-1.35), but the effect was modified by age: in younger women (18-45 years) the risk was twice as high compared to men (HR/95%-CI: 2.08/1.04-4.14), whereas the risk in elderly women (> 65 years) was only half the risk of men (HR/95%-CI: 0.47/0.24-0.93). Sex disparities occurred at different steps in the history of patients with renal disease and affected progression to dialysis, waitlisting and transplantation outcome in a population with equal access to medical treatment.