Incidence and progression of trachomatous scarring in a cohort of children in a formerly hyper-endemic district of Tanzania

Trachoma is the leading infectious cause of blindness. Repeated or persistent ocular infection with Chlamydia trachomatis in childhood leads to conjunctival scarring, usually in adulthood but often earlier in areas with greater disease burden. There are limited longitudinal data examining change in...

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Bibliographic Details
Published in:PLoS neglected tropical diseases 2020-10, Vol.14 (10), p.e0008708-e0008708
Main Authors: Kashaf, Michael Saheb, Muñoz, Beatriz E, Mkocha, Harran, Wolle, Meraf A, Naufal, Fahd, West, Sheila K
Format: Article
Language:English
Subjects:
Age
Antibiotics
Biology and Life Sciences
Blindness
Care and treatment
Child
Child, Preschool
Children
Chlamydia
Chlamydia trachomatis
Chlamydia trachomatis - isolation & purification
Chlamydia trachomatis - pathogenicity
Cicatrix - epidemiology
Cohort Studies
Cohorts
Community
Conjunctiva - diagnostic imaging
Development and progression
Disease Progression
Diseases
Female
Humans
Incidence
Infant
Infections
Inflammation
Logistic Models
Male
Management
Medical research
Medicine and Health Sciences
Medicine, Experimental
People and Places
Prevalence studies (Epidemiology)
Risk Factors
Scars
Sexually transmitted diseases
STD
Supervision
Surveying
Tanzania - epidemiology
Trachoma
Trachoma - epidemiology
Transmission
Tropical diseases
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Description
Summary:Trachoma is the leading infectious cause of blindness. Repeated or persistent ocular infection with Chlamydia trachomatis in childhood leads to conjunctival scarring, usually in adulthood but often earlier in areas with greater disease burden. There are limited longitudinal data examining change in scarring in children, especially where trachoma rates are low. A cohort of children, ages 1-9 years, were randomly selected at baseline from 38 communities in Kongwa, Tanzania and followed for 2 years. Rates of trachomatous inflammation-follicular (TF) were
ISSN:1935-2735
1935-2727
1935-2735
DOI:10.1371/journal.pntd.0008708