Outcomes of mechanically ventilated patients with COVID-19 associated respiratory failure

The outcomes of patients requiring invasive mechanical ventilation for COVID-19 remain poorly defined. We sought to determine clinical characteristics and outcomes of patients with COVID-19 managed with invasive mechanical ventilation in an appropriately resourced US health care system. Outcomes of...

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Bibliographic Details
Published in:PloS one 2020-11, Vol.15 (11), p.e0242651-e0242651
Main Authors: King, Christopher S, Sahjwani, Dhwani, Brown, A Whitney, Feroz, Saad, Cameron, Paula, Osborn, Erik, Desai, Mehul, Djurkovic, Svetolik, Kasarabada, Aditya, Hinerman, Rachel, Lantry, James, Shlobin, Oksana A, Ahmad, Kareem, Khangoora, Vikramjit, Aryal, Shambhu, Collins, A Claire, Speir, Alan, Nathan, Steven
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age
Aged
Aged, 80 and over
Anesthesia
Biology and Life Sciences
Care and treatment
Coronaviruses
COVID-19
COVID-19 - blood
COVID-19 - complications
COVID-19 - epidemiology
COVID-19 - virology
Critical care
Critical Care - standards
Dimers
Electronic health records
Electronic medical records
Engineering and Technology
Female
Ferritin
Ferritins - blood
Fibrin Fibrinogen Degradation Products - analysis
Health care
Hospital Mortality
Hospitals
Humans
Intubation
Lung diseases
Male
Mechanical ventilation
Medical prognosis
Medicine and Health Sciences
Middle Aged
Mortality
Patient Discharge
Patient outcomes
Patients
Pediatrics
Respiration, Artificial - adverse effects
Respiratory failure
Respiratory insufficiency
Respiratory Insufficiency - etiology
Respiratory Insufficiency - mortality
Retrospective Studies
SARS-CoV-2 - genetics
Survival
Ventilation
Ventilators
Virginia - epidemiology
Young Adult
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Summary:The outcomes of patients requiring invasive mechanical ventilation for COVID-19 remain poorly defined. We sought to determine clinical characteristics and outcomes of patients with COVID-19 managed with invasive mechanical ventilation in an appropriately resourced US health care system. Outcomes of COVID-19 infected patients requiring mechanical ventilation treated within the Inova Health System between March 5, 2020 and April 26, 2020 were evaluated through an electronic medical record review. 1023 COVID-19 positive patients were admitted to the Inova Health System during the study period. Of these, 164 (16.0%) were managed with invasive mechanical ventilation. All patients were followed to definitive disposition. 70/164 patients (42.7%) had died and 94/164 (57.3%) were still alive. Deceased patients were older (median age of 66 vs. 55, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0242651