Evaluation of metronomic chemotherapy response using diffusion and dynamic contrast-enhanced MRI

To investigate the feasibility of using diffusion MRI (dMRI) and dynamic contrast-enhanced (DCE) MRI to evaluate the treatment response of metronomic chemotherapy (MCT) in the 4T1 mammary tumor model of locally advanced breast cancer. Twelve Balb/c mice with metastatic breast cancer were divided int...

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Bibliographic Details
Published in:PloS one 2020-11, Vol.15 (11), p.e0241916
Main Authors: Baboli, Mehran, Winters, Kerryanne V, Freed, Melanie, Zhang, Jin, Kim, Sungheon Gene
Format: Article
Language:English
Subjects:
5-Fluorouracil
Administration, Metronomic
Angiogenesis
Animals
Antiangiogenics
Antimetabolites, Antineoplastic - administration & dosage
Antimetabolites, Antineoplastic - therapeutic use
Biology and Life Sciences
Biomarkers
Breast cancer
Cancer therapies
Care and treatment
Case-Control Studies
Chemotherapy
Contrast Media
Cytotoxicity
Diffusion
Diffusion Magnetic Resonance Imaging
Drug dosages
Evaluation
Feasibility Studies
Female
Fluorouracil - administration & dosage
Fluorouracil - therapeutic use
Longitudinal Studies
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Mammary gland
Mammary Neoplasms, Animal - diagnostic imaging
Mammary Neoplasms, Animal - drug therapy
Medicine
Medicine and Health Sciences
Metabolites
Metastases
Mice
Mice, Inbred BALB C
Neoplasm Metastasis
Patient outcomes
Prostate cancer
Research and Analysis Methods
Treatment Outcome
Tumors
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Summary:To investigate the feasibility of using diffusion MRI (dMRI) and dynamic contrast-enhanced (DCE) MRI to evaluate the treatment response of metronomic chemotherapy (MCT) in the 4T1 mammary tumor model of locally advanced breast cancer. Twelve Balb/c mice with metastatic breast cancer were divided into treated and untreated (control) groups. The treated group (n = 6) received five treatments of anti-metabolite agent 5-Fluorouracil (5FU) in the span of two weeks. dMRI and DCE-MRI were acquired for both treated and control groups before and after MCT. Immunohistochemically staining and measurements were performed after the post-MRI measurements for comparison. The control mice had significantly (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0241916