Gross appearance of the fetal membrane on the placental surface is associated with histological chorioamnionitis and neonatal respiratory disorders

An opaque fetal membrane based on gross appearance is traditionally indicative of histological chorioamnionitis; however, to the best of our knowledge, there is currently no supportive evidence, and its diagnostic efficiency has not yet been scientifically demonstrated. The present study aimed to pr...

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Bibliographic Details
Published in:PloS one 2020-11, Vol.15 (11), p.e0242579-e0242579
Main Authors: Horikoshi, Yoshimasa, Yaguchi, Chizuko, Furuta-Isomura, Naomi, Itoh, Toshiya, Kawai, Kenta, Oda, Tomoaki, Matsumoto, Masako, Kohmura-Kobayashi, Yukiko, Tamura, Naoaki, Uchida, Toshiyuki, Kanayama, Naohiro, Itoh, Hiroaki
Format: Article
Language:English
Subjects:
Adolescent
Adult
Bacterial infections
Biology and Life Sciences
Chorioamnionitis
Chorioamnionitis - etiology
Chorioamnionitis - pathology
Cohort analysis
Complications
Complications and side effects
Correlation
Diagnosis
Diagnostic systems
Extraembryonic Membranes - pathology
Female
Fetal membranes
Fetuses
Gynecology
Humans
Infant, Newborn
Infant, Newborn, Diseases - etiology
Infant, Newborn, Diseases - pathology
Infections
Medical examination
Medical research
Medicine
Medicine and Health Sciences
Membranes
Methods
Neonates
Newborn babies
Obstetrics
Pediatric respiratory diseases
Placenta
Placenta - pathology
Pregnancy
Premature Birth
Prenatal diagnosis
Regression analysis
Research and Analysis Methods
Respiratory diseases
Respiratory Tract Diseases - etiology
Respiratory Tract Diseases - pathology
Risk factors
Young Adult
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Summary:An opaque fetal membrane based on gross appearance is traditionally indicative of histological chorioamnionitis; however, to the best of our knowledge, there is currently no supportive evidence, and its diagnostic efficiency has not yet been scientifically demonstrated. The present study aimed to provide scientific insights into the traditional concept of an opaque fetal membrane based on gross appearance being an indicator of histological chorioamnionitis. We examined the placental pathology after screening of the placental gross appearance and perinatal complications and did not examine uncomplicated deliveries. We investigated the relationship between the presence of an opaque fetal membrane and histological chorioamnionitis (Cohort 1, 571 placentas) or the outcomes of neonates delivered at term (Cohort 2, 409 placentas) at Hamamatsu University School of Medicine between 2010 and 2017. The judgment of a positive opaque fetal membrane based on gross appearance correlated with histological chorioamnionitis (Cohort 1). Its sensitivity and specificity were 66.7 and 89.9%, respectively, while positive and negative predictive values were 86.8 and 73.0%, respectively. The judgment of a positive opaque fetal membrane based on gross appearance significantly correlated with chorioamnionitis-related complications in term newborns after adjustments for confounding factors (OR;1.82 [1.07-3.11], P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0242579