Risk factors of progression to endometrial cancer in women with endometrial hyperplasia: A retrospective cohort study

This study aimed to investigate risk factors of progression to endometrial cancer (EC) in women with non-atypical and atypical endometrial hyperplasia (EH). The data of 62,333 women with EH diagnostic codes from 2007 to 2018 were sourced from the Korean Health Insurance Review and Assessment Service...

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Bibliographic Details
Published in:PloS one 2020-12, Vol.15 (12), p.e0243064-e0243064
Main Authors: Jeong, Jin Young, Hwang, Sung Ook, Lee, Banghyun, Kim, Kidong, Kim, Yong Beom, Park, Sung Hye, Choi, Hwa Yeon
Format: Article
Language:English
Subjects:
Adult
Age
Biopsy
Cancer
Codes
Cohort analysis
Cohort Studies
Data analysis
Data collection
Demographic aspects
Development and progression
Diabetes
Diagnostic systems
Disease Progression
Endometrial cancer
Endometrial hyperplasia
Endometrial Hyperplasia - complications
Endometrial Hyperplasia - diagnosis
Endometrial Hyperplasia - pathology
Endometrial Neoplasms - complications
Endometrium
Female
Gynecology
Health insurance
Hospitals
Humans
Hyperplasia
Hysterectomy
Medical diagnosis
Medicine and Health Sciences
Middle Aged
Obstetrics
Patients
Retrospective Studies
Risk analysis
Risk Factors
Uterine cancer
Variance analysis
Womens health
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Summary:This study aimed to investigate risk factors of progression to endometrial cancer (EC) in women with non-atypical and atypical endometrial hyperplasia (EH). The data of 62,333 women with EH diagnostic codes from 2007 to 2018 were sourced from the Korean Health Insurance Review and Assessment Service databases. The data from 11,525 women with non-atypical EH and 2,219 women with atypical EH who met the selection criteria were extracted for analysis. Risk of EC in women with EH decreased in 40-49 year olds compared to other ages (non-atypical EH: [≤39 vs. 40-49 years] HR, 0.557; 95% CI, 0.439-0.708; P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0243064