A cross-disorder PRS-pheWAS of 5 major psychiatric disorders in UK Biobank

Psychiatric disorders are highly heritable and associated with a wide variety of social adversity and physical health problems. Using genetic liability (rather than phenotypic measures of disease) as a proxy for psychiatric disease risk can be a useful alternative for research questions that would t...

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Bibliographic Details
Published in:PLoS genetics 2020-05, Vol.16 (5), p.e1008185-e1008185
Main Authors: Leppert, Beate, Millard, Louise A C, Riglin, Lucy, Davey Smith, George, Thapar, Anita, Tilling, Kate, Walton, Esther, Stergiakouli, Evie
Format: Article
Language:English
Subjects:
Adult
Arm
Attention Deficit Disorder with Hyperactivity - epidemiology
Attention Deficit Disorder with Hyperactivity - genetics
Attention deficit hyperactivity disorder
Autism
Autism Spectrum Disorder - epidemiology
Autism Spectrum Disorder - genetics
Biological Specimen Banks - statistics & numerical data
Biology and Life Sciences
Bipolar disorder
Bipolar Disorder - epidemiology
Bipolar Disorder - genetics
Body fat
Cognition
Cohort Studies
Demography
Depressive Disorder, Major - epidemiology
Depressive Disorder, Major - genetics
Female
Genetic aspects
Genetic Heterogeneity
Genetic Predisposition to Disease
Genetic research
Genetic susceptibility
Genome-Wide Association Study - methods
Humans
Hyperactivity
Male
Medicine and Health Sciences
Mental disorders
Mental Disorders - epidemiology
Mental Disorders - genetics
Multifactorial Inheritance
Neurodevelopmental disorders
Pervasive developmental disorders
Phenotype
Risk Factors
Schizophrenia
Schizophrenia - epidemiology
Schizophrenia - genetics
Social Sciences
Socioeconomic Factors
United Kingdom - epidemiology
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Summary:Psychiatric disorders are highly heritable and associated with a wide variety of social adversity and physical health problems. Using genetic liability (rather than phenotypic measures of disease) as a proxy for psychiatric disease risk can be a useful alternative for research questions that would traditionally require large cohort studies with long-term follow up. Here we conducted a hypothesis-free phenome-wide association study in about 330,000 participants from the UK Biobank to examine associations of polygenic risk scores (PRS) for five psychiatric disorders (major depression (MDD), bipolar disorder (BP), schizophrenia (SCZ), attention-deficit/ hyperactivity disorder (ADHD) and autism spectrum disorder (ASD)) with 23,004 outcomes in UK Biobank, using the open-source PHESANT software package. There was evidence after multiple testing (p
ISSN:1553-7404
1553-7390
1553-7404
DOI:10.1371/journal.pgen.1008185