Psychological and pharmacological interventions for posttraumatic stress disorder and comorbid mental health problems following complex traumatic events: Systematic review and component network meta-analysis

Furthermore, we still do not know which treatment components are most effective and acceptable for people with PTSD following complex-trauma histories. Because of the narrow analytical focus and limitations of the current evidence base, we conducted a systematic review to identify and integrate all...

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Bibliographic Details
Published in:PLoS medicine 2020-08, Vol.17 (8), p.e1003262-e1003262
Main Authors: Coventry, Peter A., Meader, Nick, Melton, Hollie, Temple, Melanie, Dale, Holly, Wright, Kath, Cloitre, Marylène, Karatzias, Thanos, Bisson, Jonathan, Roberts, Neil P., Brown, Jennifer V. E., Barbui, Corrado, Churchill, Rachel, Lovell, Karina, McMillan, Dean, Gilbody, Simon
Format: Article
Language:English
Subjects:
Anxiety
Bias
Biology and Life Sciences
Comorbidity
Displaced persons
Domestic violence
Drug therapy
Hypnotherapy
Medicine and Health Sciences
Mental disorders
Mental health
Mental health care
Meta-analysis
Physical Sciences
Post traumatic stress disorder
Quality of life
Research and Analysis Methods
Sex crimes
Social Sciences
Systematic review
Trauma
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Summary:Furthermore, we still do not know which treatment components are most effective and acceptable for people with PTSD following complex-trauma histories. Because of the narrow analytical focus and limitations of the current evidence base, we conducted a systematic review to identify and integrate all direct and indirect comparisons of psychological and pharmacological treatments versus usual care and active controls in treating mental health problems in people with a history of complex traumatic events. Secondary outcomes were reductions in symptoms of disturbances of self-organisation (affect dysregulation; negative self-concept; disturbances in relationships); reduction in symptoms of depression and anxiety, dissociation, functional somatic syndromes; acceptability (attrition); adverse events and harms from trial data (e.g., worsening of traumatic stress symptoms); suicidal ideation, attempts, and completion; and quality of life measured by validated clinician-rated scales. Search strategy and selection criteria Literature searches were initially conducted in April 2017 in these databases: CINAHL, Cochrane Central Register of Controlled Trials (CENTRAL), Embase, International Pharmaceutical Abstracts, MEDLINE, Published International Literature on Traumatic Stress (PILOTS), PsycINFO, and Science Citation Index. [...]update searches using the MEDLINE and PsycINFO databases were carried out in October 2019.
ISSN:1549-1676
1549-1277
1549-1676
DOI:10.1371/journal.pmed.1003262