The diagnostic performance of CA125 for the detection of ovarian and non-ovarian cancer in primary care: A population-based cohort study

The serum biomarker cancer antigen 125 (CA125) is widely used as an investigation for possible ovarian cancer in symptomatic women presenting to primary care. However, its diagnostic performance in this setting is unknown. We evaluated the performance of CA125 in primary care for the detection of ov...

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Bibliographic Details
Published in:PLoS medicine 2020-10, Vol.17 (10), p.e1003295
Main Authors: Funston, Garth, Hamilton, Willie, Abel, Gary, Crosbie, Emma J, Rous, Brian, Walter, Fiona M
Format: Article
Language:English
Subjects:
Adult
Aged
Biomarkers, Tumor - blood
Breast cancer
CA-125 Antigen - analysis
CA-125 Antigen - blood
Cohort analysis
Cohort Studies
Diagnosis
Disease
Early Detection of Cancer - methods
Female
Humans
Kidney cancer
Laboratories
Mass Screening - methods
Measurement
Medical prognosis
Medical screening
Medicine and Health Sciences
Methods
Middle Aged
Neoplasms - diagnosis
Ovarian cancer
Ovarian Neoplasms - blood
Ovarian Neoplasms - diagnosis
Population
Population studies
Population-based studies
Predictive Value of Tests
Primary care
Primary Health Care
Sensitivity and Specificity
Statistical analysis
Tumor antigens
Tumors
United Kingdom
Womens health
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Summary:The serum biomarker cancer antigen 125 (CA125) is widely used as an investigation for possible ovarian cancer in symptomatic women presenting to primary care. However, its diagnostic performance in this setting is unknown. We evaluated the performance of CA125 in primary care for the detection of ovarian and non-ovarian cancers. We studied women in the United Kingdom Clinical Practice Research Datalink with a CA125 test performed between 1 May 2011-31 December 2014. Ovarian and non-ovarian cancers diagnosed in the year following CA125 testing were identified from the cancer registry. Women were categorized by age:
ISSN:1549-1676
1549-1277
1549-1676
DOI:10.1371/journal.pmed.1003295