HFpEF without elevated right ventricular systolic pressure is a favorable prognostic indicator in patients with IPF requiring hospitalization for heart failure

Some patients with idiopathic pulmonary fibrosis (IPF) must be hospitalized because of heart failure (HF), including HF with preserved ejection fraction (HFpEF) and HF with reduced EF (HFrEF). The association between IPF and HF has not been clarified. We retrospectively investigated the clinical fea...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2021-01, Vol.16 (1), p.e0245778-e0245778
Main Authors: Yamazaki, Ryo, Nishiyama, Osamu, Yoshikawa, Kazuya, Saeki, Sho, Sano, Hiroyuki, Iwanaga, Takashi, Tohda, Yuji
Format: Article
Language:English
Subjects:
Biology and Life Sciences
Blood pressure
Cardiovascular disease
Care and treatment
Congestive heart failure
Data analysis
Data collection
Diagnosis
Dyspnea
Editing
Ejection fraction
Etiology
Fibrosis
Heart failure
Hospitalization
Hospitals
Hypertension
Laboratory tests
Lung diseases
Medical prognosis
Medicine
Medicine and Health Sciences
Mortality
Oxygen
Patient outcomes
Patients
Pulmonary fibrosis
Research and Analysis Methods
Risk factors
Systolic pressure
University faculty
Variables
Ventricle
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Some patients with idiopathic pulmonary fibrosis (IPF) must be hospitalized because of heart failure (HF), including HF with preserved ejection fraction (HFpEF) and HF with reduced EF (HFrEF). The association between IPF and HF has not been clarified. We retrospectively investigated the clinical features and outcomes of patients with IPF who required nonelective hospitalization because of HF. We examined data from IPF patients who required nonelective hospitalization for HF at the Kindai University Hospital from January 2008 to December 2018. We divided the patients into 3 groups: those with HFpEF without elevated right ventricular systolic pressure (RVSP), those with HFpEF and elevated RVSP, and those with HFrEF. The recurrence rates of HF after discharge and the 30- and 90-day mortality rates of the patients were evaluated. During the study period, 37 patients with IPF required hospitalization because of HF. Among the 34 patients included in the study, 17 (50.0%) were diagnosed with HFpEF without elevated RVSP, 11 (32.3%) with HFpEF and elevated RVSP, and 6 (17.6%) with HFrEF. Patients with HFrEF had significantly higher values for B-type natriuretic peptide (BNP) and left ventricular (LV) end-systolic and end-diastolic diameters than patients with the 2 types of HFpEF (BNP: P = 0.01 and P = 0.0004, LV end-systolic diameter: P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0245778