Metabolomic analysis of uremic pruritus in patients on hemodialysis

Pruritus is a common debilitating symptom experienced by hemodialysis patients. Treatment is difficult because the cause of uremic pruritus is not known. This study addressed the hypothesis that pruritus is caused by solutes that accumulate in the plasma when the kidneys fail. We sought to identify...

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Bibliographic Details
Published in:PloS one 2021-02, Vol.16 (2), p.e0246765-e0246765
Main Authors: Bolanos, Christian G, Pham, Nhat M, Mair, Robert D, Meyer, Timothy W, Sirich, Tammy L
Format: Article
Language:English
Subjects:
Analysis
Antibiotics
Biology and Life Sciences
Causes of
Chromatography
Cirrhosis
Complications and side effects
Creatinine
Data analysis
Editing
Ethnicity
Funding
Gender
Health care
Health care facilities
Hemodialysis
Kidney diseases
Kidneys
Laboratories
Liquid chromatography
Liver cirrhosis
Liver diseases
Mass spectrometry
Mass spectroscopy
Medicine
Medicine and Health Sciences
Metabolomics
Methodology
Patients
Physical Sciences
Plasma
Principal components analysis
Pruritus
Quality of life
Research and Analysis Methods
Scientific imaging
Skin diseases
Social Sciences
Solutes
Urea
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Summary:Pruritus is a common debilitating symptom experienced by hemodialysis patients. Treatment is difficult because the cause of uremic pruritus is not known. This study addressed the hypothesis that pruritus is caused by solutes that accumulate in the plasma when the kidneys fail. We sought to identify solutes responsible for uremic pruritus using metabolomic analysis to compare the plasma of hemodialysis patients with severe pruritus versus mild/no pruritus. Pruritus severity in hemodialysis patients was assessed using a 100-mm visual analogue scale (VAS), with severe pruritus defined as >70 mm and mild/no pruritus defined as
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0246765