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Epidemiological characterization of symptomatic and asymptomatic COVID-19 cases and positivity in subsequent RT-PCR tests in the United Arab Emirates
The coronavirus disease 2019 (COVID-19) cases could be symptomatic or asymptomatic. We (1) characterized and analyzed data collected from the first cohort of reverse transcriptase polymerase chain reaction (RT-PCR)-confirmed COVID-19 cases reported in the Emirate of Abu Dhabi, United Arab Emirates,...
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Published in: | PloS one 2021-02, Vol.16 (2), p.e0246903-e0246903 |
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description | The coronavirus disease 2019 (COVID-19) cases could be symptomatic or asymptomatic. We (1) characterized and analyzed data collected from the first cohort of reverse transcriptase polymerase chain reaction (RT-PCR)-confirmed COVID-19 cases reported in the Emirate of Abu Dhabi, United Arab Emirates, according to the symptomatic state, and (2) identified factors associated with the symptomatic state. The association between the symptomatic state and testing positive in three subsequent RT-PCR testing rounds was also quantified. Between February 28 and April 8, 2020, 1,249 cases were reported. Sociodemographic characteristics, working status, travel history, and chronic comorbidities of 791 cases were analyzed according to the symptomatic state (symptomatic or asymptomatic). After the first confirmatory test, the results of three subsequent tests were analyzed. The mean age of the 791 cases was 35.6 ± 12.7 years (range: 1-81). Nearly 57.0% of cases were symptomatic. The two most frequent symptoms were fever (58.0%) and cough (41.0%). Symptomatic cases (mean age 36.3 ± 12.6 years) were significantly older than asymptomatic cases (mean age 34.5 ± 12.7 years). Compared with nonworking populations, working in public places (adjusted odds ratio (aOR), 1.76, 95% confidence interval (95% CI): 1.11-2.80), healthcare settings (aOR, 2.09, 95% CI: 1.01-4.31), or in the aviation and tourism sectors (aOR, 2.24, 95% CI: 1.14-4.40) was independently associated with the symptomatic state. Reporting at least one chronic comorbidity was also associated with symptomatic cases (aOR, 1.76, 95% CI: 1.03-3.01). Compared with asymptomatic cases, symptomatic cases had a prolonged duration of viral shedding and consistent odds of ≥2 positive COVID-19 tests result out of the three subsequent testing rounds. A substantial proportion of the diagnosed COVID-19 cases in the Emirate of Abu Dhabi were asymptomatic. Quarantining asymptomatic cases, implementing prevention measures, and raising awareness among populations working in high-risk settings are warranted. |
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We (1) characterized and analyzed data collected from the first cohort of reverse transcriptase polymerase chain reaction (RT-PCR)-confirmed COVID-19 cases reported in the Emirate of Abu Dhabi, United Arab Emirates, according to the symptomatic state, and (2) identified factors associated with the symptomatic state. The association between the symptomatic state and testing positive in three subsequent RT-PCR testing rounds was also quantified. Between February 28 and April 8, 2020, 1,249 cases were reported. Sociodemographic characteristics, working status, travel history, and chronic comorbidities of 791 cases were analyzed according to the symptomatic state (symptomatic or asymptomatic). After the first confirmatory test, the results of three subsequent tests were analyzed. The mean age of the 791 cases was 35.6 ± 12.7 years (range: 1-81). Nearly 57.0% of cases were symptomatic. The two most frequent symptoms were fever (58.0%) and cough (41.0%). Symptomatic cases (mean age 36.3 ± 12.6 years) were significantly older than asymptomatic cases (mean age 34.5 ± 12.7 years). Compared with nonworking populations, working in public places (adjusted odds ratio (aOR), 1.76, 95% confidence interval (95% CI): 1.11-2.80), healthcare settings (aOR, 2.09, 95% CI: 1.01-4.31), or in the aviation and tourism sectors (aOR, 2.24, 95% CI: 1.14-4.40) was independently associated with the symptomatic state. Reporting at least one chronic comorbidity was also associated with symptomatic cases (aOR, 1.76, 95% CI: 1.03-3.01). Compared with asymptomatic cases, symptomatic cases had a prolonged duration of viral shedding and consistent odds of ≥2 positive COVID-19 tests result out of the three subsequent testing rounds. A substantial proportion of the diagnosed COVID-19 cases in the Emirate of Abu Dhabi were asymptomatic. Quarantining asymptomatic cases, implementing prevention measures, and raising awareness among populations working in high-risk settings are warranted.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0246903</identifier><identifier>PMID: 33577582</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Age Factors ; Analysis ; Biology and Life Sciences ; Carrier State ; Comorbidity ; Coronaviruses ; COVID-19 ; COVID-19 - diagnosis ; COVID-19 - epidemiology ; COVID-19 - pathology ; COVID-19 Nucleic Acid Testing ; Delivery services ; Drafting software ; Editing ; Engineering and Technology ; Epidemiology ; Expatriates ; Gasoline ; Health care facilities ; Health centres ; Health risks ; Hotels ; Humans ; Medicine ; Medicine and Health Sciences ; Methodology ; Middle Aged ; Police ; Polymerase chain reaction ; Public health ; Research and Analysis Methods ; Retrospective Studies ; Ribonucleic acid ; RNA ; Secretions ; Security ; Service stations ; Shopping malls ; Taxicabs ; United Arab Emirates - epidemiology ; Viral diseases ; Viral infections ; Viruses</subject><ispartof>PloS one, 2021-02, Vol.16 (2), p.e0246903-e0246903</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Al-Rifai et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 Al-Rifai et al 2021 Al-Rifai et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-f6e26f8217ac82dfd1fa56402c2e6b3c3c7f5d396feefab9597e1c4c5a4294633</citedby><cites>FETCH-LOGICAL-c692t-f6e26f8217ac82dfd1fa56402c2e6b3c3c7f5d396feefab9597e1c4c5a4294633</cites><orcidid>0000-0001-6102-0353 ; 0000-0001-5292-8212</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2489021533?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2489021533?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,38516,43895,44590,53791,53793,74412,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33577582$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Samy, Abdallah M.</contributor><creatorcontrib>Al-Rifai, Rami H</creatorcontrib><creatorcontrib>Acuna, Juan</creatorcontrib><creatorcontrib>Al Hossany, Farida Ismail</creatorcontrib><creatorcontrib>Aden, Bashir</creatorcontrib><creatorcontrib>Al Memari, Shamma Abdullah</creatorcontrib><creatorcontrib>Al Mazrouei, Shereena Khamis</creatorcontrib><creatorcontrib>Ahmed, Luai A</creatorcontrib><title>Epidemiological characterization of symptomatic and asymptomatic COVID-19 cases and positivity in subsequent RT-PCR tests in the United Arab Emirates</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The coronavirus disease 2019 (COVID-19) cases could be symptomatic or asymptomatic. We (1) characterized and analyzed data collected from the first cohort of reverse transcriptase polymerase chain reaction (RT-PCR)-confirmed COVID-19 cases reported in the Emirate of Abu Dhabi, United Arab Emirates, according to the symptomatic state, and (2) identified factors associated with the symptomatic state. The association between the symptomatic state and testing positive in three subsequent RT-PCR testing rounds was also quantified. Between February 28 and April 8, 2020, 1,249 cases were reported. Sociodemographic characteristics, working status, travel history, and chronic comorbidities of 791 cases were analyzed according to the symptomatic state (symptomatic or asymptomatic). After the first confirmatory test, the results of three subsequent tests were analyzed. The mean age of the 791 cases was 35.6 ± 12.7 years (range: 1-81). Nearly 57.0% of cases were symptomatic. The two most frequent symptoms were fever (58.0%) and cough (41.0%). Symptomatic cases (mean age 36.3 ± 12.6 years) were significantly older than asymptomatic cases (mean age 34.5 ± 12.7 years). Compared with nonworking populations, working in public places (adjusted odds ratio (aOR), 1.76, 95% confidence interval (95% CI): 1.11-2.80), healthcare settings (aOR, 2.09, 95% CI: 1.01-4.31), or in the aviation and tourism sectors (aOR, 2.24, 95% CI: 1.14-4.40) was independently associated with the symptomatic state. Reporting at least one chronic comorbidity was also associated with symptomatic cases (aOR, 1.76, 95% CI: 1.03-3.01). Compared with asymptomatic cases, symptomatic cases had a prolonged duration of viral shedding and consistent odds of ≥2 positive COVID-19 tests result out of the three subsequent testing rounds. A substantial proportion of the diagnosed COVID-19 cases in the Emirate of Abu Dhabi were asymptomatic. Quarantining asymptomatic cases, implementing prevention measures, and raising awareness among populations working in high-risk settings are warranted.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Analysis</subject><subject>Biology and Life Sciences</subject><subject>Carrier State</subject><subject>Comorbidity</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>COVID-19 - diagnosis</subject><subject>COVID-19 - epidemiology</subject><subject>COVID-19 - pathology</subject><subject>COVID-19 Nucleic Acid Testing</subject><subject>Delivery services</subject><subject>Drafting software</subject><subject>Editing</subject><subject>Engineering and Technology</subject><subject>Epidemiology</subject><subject>Expatriates</subject><subject>Gasoline</subject><subject>Health care facilities</subject><subject>Health centres</subject><subject>Health risks</subject><subject>Hotels</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Methodology</subject><subject>Middle Aged</subject><subject>Police</subject><subject>Polymerase chain reaction</subject><subject>Public health</subject><subject>Research and Analysis Methods</subject><subject>Retrospective Studies</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>Secretions</subject><subject>Security</subject><subject>Service stations</subject><subject>Shopping malls</subject><subject>Taxicabs</subject><subject>United Arab Emirates - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Al-Rifai, Rami H</au><au>Acuna, Juan</au><au>Al Hossany, Farida Ismail</au><au>Aden, Bashir</au><au>Al Memari, Shamma Abdullah</au><au>Al Mazrouei, Shereena Khamis</au><au>Ahmed, Luai A</au><au>Samy, Abdallah M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epidemiological characterization of symptomatic and asymptomatic COVID-19 cases and positivity in subsequent RT-PCR tests in the United Arab Emirates</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2021-02-12</date><risdate>2021</risdate><volume>16</volume><issue>2</issue><spage>e0246903</spage><epage>e0246903</epage><pages>e0246903-e0246903</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The coronavirus disease 2019 (COVID-19) cases could be symptomatic or asymptomatic. We (1) characterized and analyzed data collected from the first cohort of reverse transcriptase polymerase chain reaction (RT-PCR)-confirmed COVID-19 cases reported in the Emirate of Abu Dhabi, United Arab Emirates, according to the symptomatic state, and (2) identified factors associated with the symptomatic state. The association between the symptomatic state and testing positive in three subsequent RT-PCR testing rounds was also quantified. Between February 28 and April 8, 2020, 1,249 cases were reported. Sociodemographic characteristics, working status, travel history, and chronic comorbidities of 791 cases were analyzed according to the symptomatic state (symptomatic or asymptomatic). After the first confirmatory test, the results of three subsequent tests were analyzed. The mean age of the 791 cases was 35.6 ± 12.7 years (range: 1-81). Nearly 57.0% of cases were symptomatic. The two most frequent symptoms were fever (58.0%) and cough (41.0%). Symptomatic cases (mean age 36.3 ± 12.6 years) were significantly older than asymptomatic cases (mean age 34.5 ± 12.7 years). Compared with nonworking populations, working in public places (adjusted odds ratio (aOR), 1.76, 95% confidence interval (95% CI): 1.11-2.80), healthcare settings (aOR, 2.09, 95% CI: 1.01-4.31), or in the aviation and tourism sectors (aOR, 2.24, 95% CI: 1.14-4.40) was independently associated with the symptomatic state. Reporting at least one chronic comorbidity was also associated with symptomatic cases (aOR, 1.76, 95% CI: 1.03-3.01). Compared with asymptomatic cases, symptomatic cases had a prolonged duration of viral shedding and consistent odds of ≥2 positive COVID-19 tests result out of the three subsequent testing rounds. A substantial proportion of the diagnosed COVID-19 cases in the Emirate of Abu Dhabi were asymptomatic. Quarantining asymptomatic cases, implementing prevention measures, and raising awareness among populations working in high-risk settings are warranted.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>33577582</pmid><doi>10.1371/journal.pone.0246903</doi><tpages>e0246903</tpages><orcidid>https://orcid.org/0000-0001-6102-0353</orcidid><orcidid>https://orcid.org/0000-0001-5292-8212</orcidid><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1932-6203 |
ispartof | PloS one, 2021-02, Vol.16 (2), p.e0246903-e0246903 |
issn | 1932-6203 1932-6203 |
language | eng |
recordid | cdi_plos_journals_2489021533 |
source | Publicly Available Content Database; PubMed Central; Coronavirus Research Database |
subjects | Adult Age Factors Analysis Biology and Life Sciences Carrier State Comorbidity Coronaviruses COVID-19 COVID-19 - diagnosis COVID-19 - epidemiology COVID-19 - pathology COVID-19 Nucleic Acid Testing Delivery services Drafting software Editing Engineering and Technology Epidemiology Expatriates Gasoline Health care facilities Health centres Health risks Hotels Humans Medicine Medicine and Health Sciences Methodology Middle Aged Police Polymerase chain reaction Public health Research and Analysis Methods Retrospective Studies Ribonucleic acid RNA Secretions Security Service stations Shopping malls Taxicabs United Arab Emirates - epidemiology Viral diseases Viral infections Viruses |
title | Epidemiological characterization of symptomatic and asymptomatic COVID-19 cases and positivity in subsequent RT-PCR tests in the United Arab Emirates |
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