G protein-coupled receptors: The choreographers of innate immunity in Caenorhabditis elegans

In this review, we examine the roles of G protein-coupled receptors (GPCRs) as noncanonical pattern recognition receptors (PRRs) and also discuss how GPCR signaling in C. elegans regulates various immune processes. The search for PRRs and immune regulators in C. elegans prompted many research groups...

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Bibliographic Details
Published in:PLoS pathogens 2021-01, Vol.17 (1), p.e1009151-e1009151
Main Authors: Venkatesh, Siddharth R, Singh, Varsha
Format: Article
Language:English
Subjects:
Analysis
Animals
Antiinfectives and antibacterials
Antimicrobial peptides
Bacterial infections
Biology and Life Sciences
Caenorhabditis elegans
Caenorhabditis elegans - immunology
Caenorhabditis elegans - metabolism
Caenorhabditis elegans - microbiology
Caenorhabditis elegans Proteins - genetics
Caenorhabditis elegans Proteins - metabolism
Damage patterns
Dopamine
Fungi - physiology
G protein-coupled receptors
G proteins
Genetic aspects
Humans
Immunity
Immunity, Innate - immunology
Immunomodulation
Immunoregulation
Infections
Innate immunity
Intestine
Kinases
Ligands
MAP kinase
Medicine and Health Sciences
Mycoses - immunology
Mycoses - metabolism
Mycoses - microbiology
Nematodes
Nervous system
Neuropeptides
Pathogens
Pattern recognition
Pattern recognition receptors
Pearls
Peptides
Protein folding
Proteins
Receptors
Receptors, G-Protein-Coupled - genetics
Receptors, G-Protein-Coupled - metabolism
Regulators
Research and Analysis Methods
Scholarships & fellowships
Signaling
Social Sciences
Worms
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Summary:In this review, we examine the roles of G protein-coupled receptors (GPCRs) as noncanonical pattern recognition receptors (PRRs) and also discuss how GPCR signaling in C. elegans regulates various immune processes. The search for PRRs and immune regulators in C. elegans prompted many research groups on a quest to identify neuronal GPCRs or GPCR signaling components that are involved in immune regulation. AMP, antimicrobial peptides; DAMP, damage-associated molecular pattern; GPCR, G protein-coupled receptor; HPLA, 4-hydroxyphenyllactic acid; UPR, unfolded protein response. https://doi.org/10.1371/journal.ppat.1009151.g001 A recent study illustrated the role for yet another neuronal GPCR in the regulation of innate immunity by modulating intestinal p38/MAPK activity. [...]far, FSHR-1 remains the only intestinal GPCR with an immunomodulatory function.
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1009151