Effects of dietary phosphates from organic and inorganic sources on parameters of phosphorus homeostasis in healthy adult dogs

The impact of dietary phosphorus (P) excess, especially on renal and cardiovascular health, has been investigated in several species, but little is known in dogs. The aim of this study was to examine effects of different P sources on concentration and postprandial kinetics of selected parameters of...

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Bibliographic Details
Published in:PloS one 2021-02, Vol.16 (2), p.e0246950-e0246950
Main Authors: Dobenecker, Britta, Reese, Sven, Herbst, Sarah
Format: Article
Language:English
Subjects:
Additives
Animal feed
Animal nutrition
Animal sciences
Biology and Life Sciences
Biomarkers
Diet
Dietetics
Dogs
Editing
Embryology
Feeds
Food
Food and nutrition
Food processing
Health aspects
Histology
Homeostasis
Kidney diseases
Medicine and Health Sciences
Nutrients
Nutrition
Nutrition research
Organic phosphorus
Palatability
Phosphates
Phosphorus
Potassium phosphate
Potassium phosphates
Poultry
Salts
Sodium phosphate
Veterinary medicine
Zoology
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Summary:The impact of dietary phosphorus (P) excess, especially on renal and cardiovascular health, has been investigated in several species, but little is known in dogs. The aim of this study was to examine effects of different P sources on concentration and postprandial kinetics of selected parameters of P homeostasis in dogs. Eight beagles received one control diet (P 0.5% dry matter [DM]) and three high P diets (poultry meal, NaH2PO4, and KH2PO4; P 1.7% DM) for 18d. Urine samples were collected pre- and postprandially while faeces were collected quantitatively for 5d and analysed for minerals. On day 18, blood was sampled 1h pre- and 0.5, 1, 1.5, 2, 3, 5 and 7h postprandially. Pi (KH2PO4, NaH2PO4) but not organic P caused an increased apparent P digestibility and significantly influenced kinetics of serum FGF23, parathyroid hormone, P, CrossLaps and bonespecific alkaline phosphatase, demonstrating a disrupted calcium (Ca) and P homeostasis with potential harm for renal, cardiovascular and skeletal health. Results of feeding Pi to dogs indicate distinct disturbances of Ca and P metabolism, in contrast to organic sources. The use of Pi in food can therefore not be considered as safe. Further research, especially on dose and long-term effects, is warranted.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0246950