Assessment of plasma BMP-2, BMP-7, BMP-10, vitamin D, and TGF β1 in simple fractures among Sudanese patients

Bone morphogenetic proteins (BMP) are multifunctional proteins. They work as cytokines regulating osteogenesis during fracture healing process. The objectives of this study were to assess changes in BMPs during fracture and their correlations to Fracture's healing. Case-Control hospital-based s...

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Published in:PloS one 2021-02, Vol.16 (2), p.e0247472-e0247472
Main Authors: Ali, Amin Ahmed, Mukhtar, Muawia Mohamed, Shaheen, Samir, Mohamed, Abdelrahim Osman
Format: Article
Language:English
Subjects:
Age
Biochemistry
Biology and Life Sciences
Black tea
Body mass
Body mass index
Body size
Bone healing
Bone morphogenetic protein 2
Bone morphogenetic protein 7
Bone surgery
Bones
Data analysis
Editing
Exercise
Fractures
Funding
Gender
Healing
Hemoglobin
Immunology
Long bone
Macrophages
Manual workers
Medicine
Medicine and Health Sciences
Nutritional status
Orthopedics
Physical sciences
Plasma
Proteins
R&D
Research & development
Research and Analysis Methods
Standard deviation
Surgery
Tea
Tibia
Transforming growth factor-b1
Trauma
Visualization
Vitamin D
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Mukhtar, Muawia Mohamed
Shaheen, Samir
Mohamed, Abdelrahim Osman
description Bone morphogenetic proteins (BMP) are multifunctional proteins. They work as cytokines regulating osteogenesis during fracture healing process. The objectives of this study were to assess changes in BMPs during fracture and their correlations to Fracture's healing. Case-Control hospital-based study conducted from January 2018 to January 2019. Demographic data, anthropometric measurements, and blood samples were collected from patients and controls (18-65 years old). Plasma concentrations of selected BMPs and vitamin D were measured using quantitative enzyme linked immunosorbent assay (ELISA). SPSS version 25 was used to calculate frequencies, Pearson correlation tests, chi-square and unpaired t-test. Sixty-five patients with fractures and Sixty-five controls were studied. Means of plasma concentrations were (TGFβ1 = 21.07 ng/ml ±8.49 and 19.8 ng/ml ±7.2) (BMP-2 = 76.3 pg/ml ± 156.6 and 55.5 ng/ml ± 127.9) (BMP-7 = 13.02 pg/ml ±43.5 and 64.6pg/ml ±250) (BMP-10 = 8.14 pg/ml ±12.7 and 5.48 pg/ml ±11.3) (Vitamin D mean was 24.94 ng/ml ±13.2 and 26.2 ng/ml ±11.6) in patients and controls, respectively. Forty-five subjects were enrolled into follow up study: 30 males, 15 females. Healing time mean was 4.13± 2.6 months. No significant correlation between BMP-2/BMP-7 with healing time. BMP-7 was significantly lowers in the plasma of patients that controls (P = 0.042). Low Vitamin D was observed among Sudanese participants.
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Means of plasma concentrations were (TGFβ1 = 21.07 ng/ml ±8.49 and 19.8 ng/ml ±7.2) (BMP-2 = 76.3 pg/ml ± 156.6 and 55.5 ng/ml ± 127.9) (BMP-7 = 13.02 pg/ml ±43.5 and 64.6pg/ml ±250) (BMP-10 = 8.14 pg/ml ±12.7 and 5.48 pg/ml ±11.3) (Vitamin D mean was 24.94 ng/ml ±13.2 and 26.2 ng/ml ±11.6) in patients and controls, respectively. Forty-five subjects were enrolled into follow up study: 30 males, 15 females. Healing time mean was 4.13± 2.6 months. No significant correlation between BMP-2/BMP-7 with healing time. BMP-7 was significantly lowers in the plasma of patients that controls (P = 0.042). 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They work as cytokines regulating osteogenesis during fracture healing process. The objectives of this study were to assess changes in BMPs during fracture and their correlations to Fracture's healing. Case-Control hospital-based study conducted from January 2018 to January 2019. Demographic data, anthropometric measurements, and blood samples were collected from patients and controls (18-65 years old). Plasma concentrations of selected BMPs and vitamin D were measured using quantitative enzyme linked immunosorbent assay (ELISA). SPSS version 25 was used to calculate frequencies, Pearson correlation tests, chi-square and unpaired t-test. Sixty-five patients with fractures and Sixty-five controls were studied. 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subjects Age
Biochemistry
Biology and Life Sciences
Black tea
Body mass
Body mass index
Body size
Bone healing
Bone morphogenetic protein 2
Bone morphogenetic protein 7
Bone surgery
Bones
Data analysis
Editing
Exercise
Fractures
Funding
Gender
Healing
Hemoglobin
Immunology
Long bone
Macrophages
Manual workers
Medicine
Medicine and Health Sciences
Nutritional status
Orthopedics
Physical sciences
Plasma
Proteins
R&D
Research & development
Research and Analysis Methods
Standard deviation
Surgery
Tea
Tibia
Transforming growth factor-b1
Trauma
Visualization
Vitamin D
title Assessment of plasma BMP-2, BMP-7, BMP-10, vitamin D, and TGF β1 in simple fractures among Sudanese patients
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