Retrospective study of late radiation-induced damages after focal radiotherapy for childhood brain tumors

To study a robust and reproducible procedure to investigate a relation between focal brain radiotherapy (RT) low doses, neurocognitive impairment and late White Matter and Gray Matter alterations, as shown by Diffusion Tensor Imaging (DTI), in children. Forty-five patients (23 males and 22 females,...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2021-02, Vol.16 (2), p.e0247748-e0247748
Main Authors: Cavatorta, Claudia, Meroni, Silvia, Montin, Eros, Oprandi, Maria C, Pecori, Emilia, Lecchi, Mara, Diletto, Barbara, Alessandro, Ombretta, Peruzzo, Denis, Biassoni, Veronica, Schiavello, Elisabetta, Bologna, Marco, Massimino, Maura, Poggi, Geraldina, Mainardi, Luca, Arrigoni, Filippo, Spreafico, Filippo, Verderio, Paolo, Pignoli, Emanuele, Gandola, Lorenza
Format: Article
Language:English
Subjects:
Algorithms
Auroral kilometric radiation
Bioengineering
Bioinformatics
Biology and Life Sciences
Brain cancer
Brain damage
Brain tumors
Care and treatment
Children
Cognition
Cognitive ability
Complications
Computed tomography
Computer programs
Correlation analysis
Diagnosis
Dosage and administration
Editing
Electronics
Enrollments
Guardians
Health physics
Health services
Magnetic resonance imaging
Medical imaging
Medicine and Health Sciences
Methodology
Methods
Neuroimaging
Neurotoxicity
Oncology
Patient outcomes
Patients
Pediatrics
Physics
Planning
Quality of life
Radiation
Radiation damage
Radiation dosage
Radiation effects
Radiation therapy
Radiotherapy
Registration
Rehabilitation
Research and Analysis Methods
Risk analysis
Risk factors
Social Sciences
Software
Testing
Tumors
Tumors in children
Workflow
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To study a robust and reproducible procedure to investigate a relation between focal brain radiotherapy (RT) low doses, neurocognitive impairment and late White Matter and Gray Matter alterations, as shown by Diffusion Tensor Imaging (DTI), in children. Forty-five patients (23 males and 22 females, median age at RT 6.2 years, median age at evaluations 11.1 years) who had received focal RT for brain tumors were recruited for DTI exams and neurocognitive tests. Patients' brains were parceled in 116 regions of interest (ROIs) using an available segmented atlas. After the development of an ad hoc, home-made, multimodal and highly deformable registration framework, we collected mean RT doses and DTI metrics values for each ROI. The pattern of association between cognitive scores or domains and dose or DTI values was assessed in each ROI through both considering and excluding ROIs with mean doses higher than 75% of the prescription. Subsequently, a preliminary threshold value of dose discriminating patients with and without neurocognitive impairment was selected for the most relevant associations. The workflow allowed us to identify 10 ROIs where RT dose and DTI metrics were significantly associated with cognitive tests results (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0247748