Rhabdomyolysis related to acute recreational drug toxicity-A Euro-DEN study

This study was conducted to retrospectively assess the relationships between: rhabdomyolysis (quantified by creatine kinase (CK) activity) and kidney injury (quantified by serum creatinine concentration), sex, age, body temperature on admission, presence of seizures, and agitation or aggression in p...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2021-03, Vol.16 (3), p.e0246297
Main Authors: Waldman, Wojciech, Kabata, Piotr M, Dines, Alison M, Wood, David M, Yates, Christopher, Heyerdahl, Fridtjof, Hovda, Knut Erik, Giraudon, Isabelle, Dargan, Paul I, Sein Anand, Jacek
Format: Article
Language:English
Subjects:
Aggression
Agitation
Biology and Life Sciences
Body temperature
Care and treatment
Creatine
Creatine kinase
Creatinine
Data collection
Datasets
Diagnosis
Disintegration
Drafting software
Drug abuse
Drug addiction
Drugs
Ecstasy
Editing
Health aspects
Hospitals
Hyperthermia
Kidneys
Kinases
Life sciences
Medicine
Medicine and Health Sciences
Muscles
Myoglobins
Patients
Physical Sciences
Poisons
Recreational drugs
Rhabdomyolysis
Seizures
Skeletal muscle
Toxicity
Toxicology
Values
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study was conducted to retrospectively assess the relationships between: rhabdomyolysis (quantified by creatine kinase (CK) activity) and kidney injury (quantified by serum creatinine concentration), sex, age, body temperature on admission, presence of seizures, and agitation or aggression in patients presenting to the Emergency Department with acute recreational drug toxicity. We also investigated the association with the substances ingested. All presentations to the 16 sentinel Euro-DEN centres in 10 European countries with acute recreational drug toxicity during the first year of the Euro-DEN study (October 2013 to September 2014) were considered. Cases that had abnormal CK activity recorded as part of routine clinical care were divided into 3 cohorts depending on peak CK activity. Cases with normal CK activity were included as a control group (4th cohort). Only 1,015 (18.4%) of the 5,529 Euro-DEN presentations had CK activity concentration recorded. Of this group 353 (34.8%) had also creatinine concentration measured. There were 375 (36.9%) with minor rhabdomyolysis, 69 (6.8%) with moderate rhabdomyolysis, and 24 (2.4%) with severe rhabdomyolysis; 547 (53.9%) were included in the control group. There was a positive correlation between CK activity and creatinine concentration (correlation coefficient r = 0.71, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0246297