Diagnostic and prognostic ability of salivary MMP-9 for oral squamous cell carcinoma: A pre-/post-surgery case and matched control study

Over 90% of oral cancers are oral squamous cell carcinoma (OSCC). Hitherto, early detection marker for OSCC has not been available. Hence, this study aimed to evaluate the diagnostic and prognostic ability of salivary matrix-metalloproteinase-9 (MMP-9) and 8-hydroxydeoxyguanosine (8-OHdG) for OSCC....

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Bibliographic Details
Published in:PloS one 2021-03, Vol.16 (3), p.e0248167-e0248167
Main Authors: Shin, Yoo-Jin, Vu, Huong, Lee, Jong-Ho, Kim, Hyun-Duck
Format: Article
Language:English
Subjects:
Age
Aquatic birds
Biology and Life Sciences
Biomarkers
Biopsy
Cancer
Dental research
Dentistry
Diabetes
Diagnosis
Editing
Gelatinase B
Gum disease
Head & neck cancer
Head and neck cancer
Hospitals
Human subjects
Larynx
Maxillofacial
Maxillofacial surgery
Medical diagnosis
Medical prognosis
Medicine and Health Sciences
Methodology
Morbidity
Obesity
Oral cancer
Oral cavity
Oral squamous cell carcinoma
Oropharynx
Patients
Physiological aspects
Prognosis
Sample size
Sociodemographics
Squamous cell carcinoma
Surgery
Survival
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Summary:Over 90% of oral cancers are oral squamous cell carcinoma (OSCC). Hitherto, early detection marker for OSCC has not been available. Hence, this study aimed to evaluate the diagnostic and prognostic ability of salivary matrix-metalloproteinase-9 (MMP-9) and 8-hydroxydeoxyguanosine (8-OHdG) for OSCC. Total of 318 participants with 106 cases and 212 controls were included: OSCC cases were from Seoul National University Dental Hospital and age, sex, and smoking matched controls were from Yangpyeong cohort. Unstimulated saliva was collected to determine MMP-9 and 8-OHdG using sensitive enzyme-linked immunosorbent assay. Multivariable linear regression and analysis of covariance (ANCOVA) were applied to evaluate the adjusted association of markers with OSCC. Wilcoxon sign rank sum test and Friedman test for median were applied to evaluate follow-up level of MMP-9 after surgery. Receiver operating characteristic curve was obtained for diagnostic ability. Salivary MMP-9 was associated with OSCC (ANCOVA and multivariable linear regression, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0248167