Prognostic factors of chronic pulmonary aspergillosis: A retrospective cohort of 264 patients from Japan

Chronic pulmonary aspergillosis (CPA) develops in various underlying pulmonary conditions. There is scarce data evaluating interstitial lung disease (ILD)/abnormalities (ILA) as such conditions, and it has not been explored much whether non-tuberculous mycobacterial pulmonary disease (NTM-PD) is a p...

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Published in:PloS one 2021-04, Vol.16 (4), p.e0249455-e0249455
Main Authors: Kimura, Yuya, Sasaki, Yuka, Suzuki, Junko, Suzuki, Jun, Igei, Hiroshi, Suzukawa, Maho, Matsui, Hirotoshi
Format: Article
Language:English
Subjects:
Antibodies
Antigens
Aspergilloma
Aspergillosis
Biology and Life Sciences
Body mass index
C-reactive protein
Calcification
Chronic obstructive pulmonary disease
Computed tomography
Corticoids
Corticosteroids
Drafting software
Editing
Emphysema
Fungal infections
Hospitals
Infectious diseases
Interferon
Lung diseases
Lymph nodes
Medical imaging
Medical prognosis
Medical records
Medical referrals
Medicine
Medicine and Health Sciences
Methodology
Multivariate analysis
Patients
Prognosis
Public health
Pulmonary aspergillosis
Pulmonary fibrosis
Serum albumin
Software
Statistics
Thoracic surgery
Tuberculosis
Variables
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Summary:Chronic pulmonary aspergillosis (CPA) develops in various underlying pulmonary conditions. There is scarce data evaluating interstitial lung disease (ILD)/abnormalities (ILA) as such conditions, and it has not been explored much whether non-tuberculous mycobacterial pulmonary disease (NTM-PD) is a prognostic factor for mortality in CPA patients. Few reports had investigated prognostic factors of CPA including underlying pulmonary conditions. To explore prognostic factors of CPA including pulmonary conditions. We conducted a retrospective cohort study of 264 CPA patients from a center for pulmonary aspergillosis in Japan. Survival rates were 78.7%, 61.0%, and 47.4% at 1, 3, and 5 years, respectively. Of 264 patients, 53 (20.1%) and 87 (33.1%) were complicated with ILA and NTM-PD. Several independent prognostic factors were identified by multivariate Cox proportional analysis: ILA (HR 1.76, 95%CI 1.06-2.92, p = 0.029), age (1.05, 1.02-1.08, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0249455