COVID-19 infection with asymptomatic or mild disease severity in young patients: Clinical course and association between prevalence of pneumonia and viral load

Few studies have focused on clinical courses or viral loads in young asymptomatic or mild patients with COVID-19 infection. We sought to better understand the clinical course and association between viral load and prevalence of pneumonia in young COVID-19 patients with asymptomatic or mild disease s...

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Published in:PloS one 2021-04, Vol.16 (4), p.e0250358-e0250358
Main Authors: Kim, Cherry, Kim, Wooil, Jeon, Ji Hoon, Seok, Hyeri, Kim, Sun Bean, Choi, Hee Kyoung, Yoon, Young Kyung, Song, Joon Young, Park, Dae Won, Sohn, Jang Wook, Choi, Won Suk
Format: Article
Language:English
Subjects:
Adolescent
Adult
Asymptomatic
Asymptomatic Diseases - epidemiology
Bacterial pneumonia
Biology and Life Sciences
Children
Computed tomography
Computer programs
Coronaviruses
COVID-19
COVID-19 - epidemiology
COVID-19 - metabolism
Data analysis
Development and progression
Drafting software
Dyspnea
Editing
Female
Health aspects
Hospitals
Humans
Infections
Infectious diseases
Internal medicine
Male
Medical imaging
Medical schools
Medicine
Medicine and Health Sciences
Methodology
Oxygen
Oxygen therapy
Patients
Physical Sciences
Pneumonia
Pneumonia - epidemiology
Prevalence
Public health
Quarantine
Radiology
Republic of Korea
Respiration
Retrospective Studies
SARS-CoV-2 - isolation & purification
Serologic Tests
Severe acute respiratory syndrome coronavirus 2
Severity of Illness Index
Software
Tachypnea
Viral diseases
Viral Load - methods
Young Adult
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creator Kim, Cherry
Kim, Wooil
Jeon, Ji Hoon
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Sohn, Jang Wook
Choi, Won Suk
description Few studies have focused on clinical courses or viral loads in young asymptomatic or mild patients with COVID-19 infection. We sought to better understand the clinical course and association between viral load and prevalence of pneumonia in young COVID-19 patients with asymptomatic or mild disease severity. In this retrospective study, 106 COVID-19 young patients with asymptomatic or mild disease severity were analyzed for clinical characteristics, clinical course, prevalence of radiologically proven pneumonia and viral load. The cut-off value of viral load for presence of pneumonia was also investigated. The mean age was 28.0±9.3 years. Eleven patients (10.4%) experienced viral remission within one week of diagnosis, but one (0.9%) transferred to the hospital due to aggravation of pneumonia. Patients with pneumonia had significantly higher viral load than those without, and the cut-off value of the Ct value for presence of pneumonia were 31.38. The patients with pneumonia had significantly slower recovery times than those without. Diarrhea was significantly more common in patients with pneumonia than patients without pneumonia. In conclusion, most young asymptomatic and mildly symptomatic patients showed stable clinical course. There were significant differences in viral load and recovery times between patients with and without pneumonia.
doi_str_mv 10.1371/journal.pone.0250358
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recordid cdi_plos_journals_2516206052
source PubMed Central (Open Access); Publicly Available Content Database; Coronavirus Research Database
subjects Adolescent
Adult
Asymptomatic
Asymptomatic Diseases - epidemiology
Bacterial pneumonia
Biology and Life Sciences
Children
Computed tomography
Computer programs
Coronaviruses
COVID-19
COVID-19 - epidemiology
COVID-19 - metabolism
Data analysis
Development and progression
Drafting software
Dyspnea
Editing
Female
Health aspects
Hospitals
Humans
Infections
Infectious diseases
Internal medicine
Male
Medical imaging
Medical schools
Medicine
Medicine and Health Sciences
Methodology
Oxygen
Oxygen therapy
Patients
Physical Sciences
Pneumonia
Pneumonia - epidemiology
Prevalence
Public health
Quarantine
Radiology
Republic of Korea
Respiration
Retrospective Studies
SARS-CoV-2 - isolation & purification
Serologic Tests
Severe acute respiratory syndrome coronavirus 2
Severity of Illness Index
Software
Tachypnea
Viral diseases
Viral Load - methods
Young Adult
title COVID-19 infection with asymptomatic or mild disease severity in young patients: Clinical course and association between prevalence of pneumonia and viral load
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