A prolonged hiatus in postmenopausal HRT, does not nullify the therapy's positive impact on ageing related sarcopenia

Previous work suggest a positive skeletal muscle effect of hormone replacement therapy (HRT) on skeletal muscle characteristics This study aimed to quantify any continued positive effect of HRT even after a sustained hiatus in treatment, controlling for two key muscle modulation hormones: Estradiol...

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Bibliographic Details
Published in:PloS one 2021-05, Vol.16 (5), p.e0250813-e0250813
Main Authors: Onambélé-Pearson, Gladys L, Tomlinson, David J, Morse, Christopher I, Degens, Hans
Format: Article
Language:English
Subjects:
17β-Estradiol
Age
Aging
Atrophy
Biology and Life Sciences
Body composition
Body fat
Complications and side effects
Estrogens
Exercise
Females
Fibers
Genotype & phenotype
Glycolysis
Health aspects
Hormone replacement therapy
Hormone therapy
Isokinetic strength
Laboratories
Medicine
Medicine and Health Sciences
Menopause
Muscle contraction
Muscle function
Muscles
Musculoskeletal system
Phenotypes
Physical fitness
Physical Sciences
Post-menopause
Postmenopausal women
Questionnaires
Sarcopenia
Sex hormones
Skeletal muscle
Software
Structure-function relationships
Thyroid gland
Womens health
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Summary:Previous work suggest a positive skeletal muscle effect of hormone replacement therapy (HRT) on skeletal muscle characteristics This study aimed to quantify any continued positive effect of HRT even after a sustained hiatus in treatment, controlling for two key muscle modulation hormones: Estradiol (E2) and Tri-iodo-thyronine (T3). In 61 untrained women (18-78yrs) stratified as pre-menopausal, post-menopausal without (No_HRT) and post-menopausal with (Used_HRT) HRT history, body composition, physical activity, serum E2 and T3 were assessed by dual energy x-ray absorptiometry, Baecke questionnaire and ELISA. Gastrocnemius medialis (GM) and tibialis anterior (TA) electromyographic profiles (mean power frequency (mPowerF)), isometric plantar-flexion (PF) and dorsi-flexion (DF) maximum voluntary contraction (MVC), rate of torque development (RTD), isokinetic MVC and muscle volume, were assessed using surface electromyography, dynamometry and ultrasonography. Muscle quality was quantified as MVC per unit muscle size. E2 and E2:T3 ratio were significantly lower in postmenopausal participants, and were positively correlated with RTD even after controlling for adiposity and/or age. Pre-menopausal females had greater MVC in 8/8 PF and 2/5 DF (23.7-98.1%; P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0250813