Cell behavior on silica-hydroxyapatite coaxial composite

Progress in the manufacture of scaffolds in tissue engineering lies in the successful combination of materials such as bioceramics having properties as porosity, biocompatibility, water retention, protein adsorption, mechanical strength and biomineralization. Hydroxyapatite (HA) is a ceramic materia...

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Bibliographic Details
Published in:PloS one 2021-05, Vol.16 (5), p.e0246256-e0246256
Main Authors: Garibay-Alvarado, Jesús Alberto, Herrera-Ríos, Ericka Berenice, Vargas-Requena, Claudia Lucía, de Jesús Ruíz-Baltazar, Álvaro, Reyes-López, Simón Yobanny
Format: Article
Language:English
Subjects:
Antibacterial activity
Bioceramics
Biocompatibility
Biology and Life Sciences
Biomedical materials
Bone regeneration
Calcium phosphates
Cell differentiation
Ceramic fibers
Composite materials
Design and construction
Editing
Electron microscopy
Engineering and Technology
Ethanol
Fourier analysis
Fourier transforms
Health aspects
Hyaluronic acid
Hydrogels
Hydroxyapatite
Infrared spectra
Materials research
Mechanical properties
Medicine and Health Sciences
Methodology
Mineralization
Nanoparticles
Nitrates
Optics
Physical Sciences
Platinum
Porosity
Protein adsorption
Reflectance
Research and analysis methods
Reviews
Scanning electron microscopy
Silica
Silicon dioxide
Silk
Silver
Spectroscopy
Spectrum analysis
Structure
Tissue engineering
Wavelengths
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Summary:Progress in the manufacture of scaffolds in tissue engineering lies in the successful combination of materials such as bioceramics having properties as porosity, biocompatibility, water retention, protein adsorption, mechanical strength and biomineralization. Hydroxyapatite (HA) is a ceramic material with lots of potential in tissue regeneration, however, its structural characteristics need to be improved for better performance. In this study, silica-hydroxyapatite (SiO2-HA) non-woven ceramic electrospunned membranes were prepared through the sol-gel method. Infrared spectra, scanning electron microscopy and XRD confirmed the structure and composition of composite. The obtained SiO2-HA polymeric fibers had approximately 230±20 nm in diameter and were then sintered at 800°C average diameter decreased to 110±17 nm. Three configurations of the membranes were obtained and tested in vitro, showing that the composite of SiO2-HA fibers showed a high percentage of viability on a fibroblast cell line. It is concluded that the fibers of SiO2-HA set in a coaxial configuration may be helpful to develop materials for bone regeneration.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0246256