Cloning of a HcCreb gene and analysis of its effects on nacre color and melanin synthesis in Hyriopsis cumingii

Creb (Cyclic AMP response element binding protein) is a nuclear regulatory factor that regulates transcription through autophosphorylation. In melanocytes, cAMP's corresponding elements bind to the Creb protein to autophosphorylation and activate MITF (Microphthalmia-associated transcription fa...

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Bibliographic Details
Published in:PloS one 2021-05, Vol.16 (5), p.e0251452
Main Authors: Zhang, Mengying, Chen, Xiajun, Zhang, Jinpan, Li, Jiale, Bai, Zhiyi
Format: Article
Language:English
Subjects:
Agricultural resources
Agricultural sciences
Agriculture
Amino acids
AMP
Aquaculture
Aquatic animals
Biology and Life Sciences
Biosynthesis
Breeding
Calcium carbonate
Carotenoids
Cloning
Collaboration
Cyclic AMP
Cyclic AMP response element-binding protein
Earth Sciences
Engineering research
Fresh water
Funding
Gene expression
Genes
Genetic aspects
Genetic resources
Genetics
Innovations
Laboratories
Melanin
Methods
Mollusks
Mussels, Fresh-water
Nacre
Oceans
Optical properties
Physical Sciences
Physiological aspects
Physiology
Proteins
Regulation
Research and Analysis Methods
Research facilities
Shells
Transcription factors
Transcriptomes
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Summary:Creb (Cyclic AMP response element binding protein) is a nuclear regulatory factor that regulates transcription through autophosphorylation. In melanocytes, cAMP's corresponding elements bind to the Creb protein to autophosphorylation and activate MITF (Microphthalmia-associated transcription factor). MITF stimulates Tyrosine(tyr) to induce melanocytes to differentiate into eumelanin and pheomelanin. In this study, a HcCreb gene in Hyriopsis cumingii was cloned and its effects on melanin synthesis and nacre color were studied. HcCreb was expressed in both purple and white mussels, and there was a significant difference in expression between adductor muscle (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0251452