Spatial heterogeneity of cutaneous blood flow respiratory-related oscillations quantified via laser speckle contrast imaging

LSCI technique provides experimental data which can be considered in the context of spatial blood flow coherency. Analysis of vascular tone oscillations gives additional information to ensure a better understanding of the mechanisms affecting microvascular physiology. The oscillations with different...

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Bibliographic Details
Published in:PloS one 2021-05, Vol.16 (5), p.e0252296-e0252296
Main Authors: Mizeva, Irina, Potapova, Elena, Dremin, Viktor, Kozlov, Igor, Dunaev, Andrey
Format: Article
Language:English
Subjects:
Analysis
Assessment
Biology and Life Sciences
Biomedical engineering
Blood
Blood flow
Cameras
Data analysis
Drafting software
Editing
Engineering and Technology
Flow
Heterogeneity
Hypotheses
Lasers
Medicine and Health Sciences
Microvasculature
Nervous system
Oscillations
Peripheral blood
Photonics
Physical Sciences
Physiology
R&D
Research & development
Research and Analysis Methods
Respiration
Respiratory organs
Reviews
Signal processing
Spatial distribution
Spatial heterogeneity
Spatial variations
Spectral analysis
Spectrum analysis
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Summary:LSCI technique provides experimental data which can be considered in the context of spatial blood flow coherency. Analysis of vascular tone oscillations gives additional information to ensure a better understanding of the mechanisms affecting microvascular physiology. The oscillations with different frequencies are due to different physiological mechanisms. The reasons for the generation of peripheral blood flow oscillations in the 0.14-0.6 Hz frequency band are as follows: cardio-respiratory interactions, pressure variations in the venous part of the circulatory system, and the effect of the sympathetic nervous system on the vascular tone. Earlier, we described the spatial heterogeneity of around 0.3 Hz oscillations and this motivated us to continue the research to find the conditions for the occurrence of spatial phase synchronization. For this purpose, a number of physiological tests (controlled respiration, breath holder, and venous occlusion tests) which influence the blood flow oscillations of 0.14-0.6 Hz were considered, an appropriate measurement system and the required data processing algorithms were developed. At spontaneous respiration, the oscillations with frequencies around 0.3 Hz were stochastic, whereas all the performed tests induced an increase in spatial coherence. The protocols and methods proposed here can help to clarify whether the heterogeneity of respiratory-related blood flow oscillations exists on the skin surface.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0252296