Value of spectral detector computed tomography for the early assessment of technique efficacy after microwave ablation of hepatocellular carcinoma

To investigate whether virtual monoenergetic images (VMI) and iodine maps derived from spectral detector computed tomography (SDCT) improve early assessment of technique efficacy in patients who underwent microwave ablation (MWA) for hepatocellular carcinoma (HCC) in liver cirrhosis. This retrospect...

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Bibliographic Details
Published in:PloS one 2021-06, Vol.16 (6), p.e0252678-e0252678
Main Authors: Reimer, Robert Peter, Hokamp, Nils Große, Niehoff, Julius, Zopfs, David, Lennartz, Simon, Heidar, Mariam, Wahba, Roger, Stippel, Dirk, Maintz, David, dos Santos, Daniel Pinto, Wybranski, Christian
Format: Article
Language:English
Subjects:
Ablation
Ablation (Surgery)
Biology and Life Sciences
Cancer
Care and treatment
Computed tomography
Conspicuity
CT imaging
Data analysis
Diagnostic systems
Editing
Energy
Evaluation
Global health
Hepatocellular carcinoma
Hepatoma
Hospitals
Hybrid systems
Information systems
Iodine
Liver
Liver cancer
Magnetic resonance imaging
Medical imaging
Medicine
Medicine and Health Sciences
Methodology
Microwave ablation
Patient outcomes
Physical Sciences
Public health
Radiology
Research and Analysis Methods
Sensors
Surgery
Visualization
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Summary:To investigate whether virtual monoenergetic images (VMI) and iodine maps derived from spectral detector computed tomography (SDCT) improve early assessment of technique efficacy in patients who underwent microwave ablation (MWA) for hepatocellular carcinoma (HCC) in liver cirrhosis. This retrospective study comprised 39 patients with 49 HCC lesions treated with MWA. Biphasic SDCT was performed 7.7±4.0 days after ablation. Conventional images (CI), VMI and IM were reconstructed. Signal- and contrast-to-noise ratio (SNR, CNR) in the ablation zone (AZ), hyperemic rim (HR) and liver parenchyma were calculated using regions-of-interest analysis and compared between CI and VMI between 40-100 keV. Iodine concentration and perfusion ratio of HR and residual tumor (RT) were measured. Two readers evaluated subjective contrast of AZ and HR, technique efficacy (complete vs. incomplete ablation) and diagnostic confidence at determining technique efficacy. Attenuation of liver parenchyma, HR and RT, SNR of liver parenchyma and HR, CNR of AZ and HR were significantly higher in low-keV VMI compared to CI (all p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0252678