Male gender is a predictor of higher mortality in hospitalized adults with COVID-19

The coronavirus disease 2019 (COVID-19) pandemic continues to be a global threat, with tremendous resources invested into identifying risk factors for severe COVID-19 illness. The objective of this study was to analyze the characteristics and outcomes of male compared to female adults with COVID-19...

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Bibliographic Details
Published in:PloS one 2021-07, Vol.16 (7), p.e0254066-e0254066
Main Authors: Nguyen, Ninh T, Chinn, Justine, De Ferrante, Morgan, Kirby, Katharine A, Hohmann, Samuel F, Amin, Alpesh
Format: Article
Language:English
Subjects:
Adolescent
Adult
Adults
Age
Age groups
Aged
Aged, 80 and over
Biology and Life Sciences
Congestive heart failure
Coronaviruses
COVID-19
COVID-19 - drug therapy
COVID-19 - mortality
Demographic aspects
Demographics
Demography
Diabetes
Diabetes mellitus
Disease control
Ethnicity
Female
Females
Gender
Gender differences
Health risks
Heart failure
Hormones
Hospital Mortality
Hospital patients
Hospitalization
Hospitals
Humans
Hydrologic data
Hypertension
Intubation
Length of stay
Liver diseases
Lung diseases
Male
Males
Mechanical ventilation
Medicine and Health Sciences
Middle Aged
Minority & ethnic groups
Mortality
Obesity
Pandemics
Patient outcomes
People and Places
Race
Renal failure
Respiration
Risk analysis
Risk factors
Sex Characteristics
Sex Factors
Sexes
Software
United States
Ventilation
Viral diseases
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Summary:The coronavirus disease 2019 (COVID-19) pandemic continues to be a global threat, with tremendous resources invested into identifying risk factors for severe COVID-19 illness. The objective of this study was to analyze the characteristics and outcomes of male compared to female adults with COVID-19 who required hospitalization within US academic centers. Using the Vizient clinical database, discharge records of adults with a diagnosis of COVID-19 between March 1, 2020 and November 30, 2020 were reviewed. Outcome measures included demographics, characteristics, length of hospital stay, rate of respiratory intubation and mechanical ventilation, and rate of in-hospital mortality of male vs female according to age, race/ethnicity, and presence of preexisting comorbidities. Among adults with COVID-19, 161,206 were male while 146,804 were female. Adult males with COVID-19 were more likely to have hypertension (62.1% vs 59.6%, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0254066