Incidence, associated risk factors, and the ideal mode of delivery following preterm labour between 24 to 28 weeks of gestation in a low resource setting

• Published in: PloS one 2021-07, Vol.16 (7), p.e0254801-e0254801
• Main Authors: Kayiga, Herbert, Achanda Genevive, Diane, Amuge, Pauline Mary, Byamugisha, Josaphat, Nakimuli, Annettee, Jones, Andrew
• Format: Article
• Language: English
• Subjects: Amniotic fluid; Babies; Biology and Life Sciences; Births; Central business districts; Chi-square test; Childbirth; Complications and side effects; Corticoids; Corticosteroids; Delivery, Obstetric; Female; Fever; Gestation; Gynecology; Health risks; Health sciences; Hemorrhage; Hospitals; Humans; Incidence; Infant, Newborn; Infants; Infections; Medical referrals; Medicine and Health Sciences; Mortality; Mothers; Multivariate analysis; Neonates; Nurses; Obstetric Labor, Premature - mortality; Obstetrics; Patient outcomes; Patients; Perinatal Death; Perinatal Mortality; Pregnancy; Premature birth; Premature Birth - mortality; Premature labor; Prospective Studies; Resuscitation; Risk analysis; Risk Factors; Sepsis - mortality; Statistical tests; Streamlining; Uganda - epidemiology; Ultrasonic imaging; Vagina; Womens health
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0254801

Preterm labour, between 24 to 28 weeks of gestation, remains prevalent in low resource settings. There is evidence of improved survival after 24 weeks though the ideal mode of delivery remains unclear. There are no clear management protocols to guide patient management. We sought to determine the incidence of preterm labour occurring between 24 to 28 weeks, its associated risk factors and the preferred mode of delivery in a low resource setting with the aim of streamlining patient care. Between February 2020 and September 2020, we prospectively followed 392 women with preterm labour between 24 to 28 weeks of gestation and their newborns from admission to discharge at Kawempe National Referral hospital in Kampala, Uganda. The primary outcome was perinatal mortality associated with the different modes of delivery. Secondary outcomes included neonatal and maternal infections, admission to the Neonatal Special Care Unit (SCU), need for neonatal resuscitation, preterm birth and maternal death. Chi-square test was used to assess the association between perinatal mortality and categorical variables such as parity, mode of delivery, employment status, age, antepartum hemorrhage, digital vaginal examination, and admission to Special Care unit. Multivariate logistic regression was used to assess the association between comparative outcomes of the different modes of delivery and maternal and neonatal risk factors. The incidence of preterm labour among women who delivered preterm babies between 24 to 28 weeks was 68.9% 95% CI 64.2-73.4). Preterm deliveries between 24 to 28 weeks contributed 20% of the all preterm deliveries and 2.5% of the total hospital deliveries. Preterm labour was independently associated with gravidity (p-value = 0.038), whether labour was medically induced (p-value