Field evaluation of the gut microbiome composition of pre-school and school-aged children in Tha Song Yang, Thailand, following oral MDA for STH infections

Soil-transmitted helminths, such as roundworms (Ascaris lumbricoides), whipworms (Trichuris trichiura) and hookworms (Necator americanus and Ancylostoma spp.), are gastrointestinal parasites that occur predominantly in low- to middle-income countries worldwide and disproportionally impact children....

Full description

Saved in:
Bibliographic Details
Published in:PLoS neglected tropical diseases 2021-07, Vol.15 (7), p.e0009597
Main Authors: Stracke, Katharina, Adisakwattana, Poom, Phuanukoonnon, Suparat, Yoonuan, Tippayarat, Poodeepiyasawat, Akkarin, Dekumyoy, Paron, Chaisiri, Kittipong, Roth Schulze, Alexandra, Wilcox, Stephen, Karunajeewa, Harin, Traub, Rebecca J, Jex, Aaron R
Format: Article
Language:English
Subjects:
Anaemia
Anemia
Anthelmintics - administration & dosage
Anthelmintics - therapeutic use
Ascaris lumbricoides
Biology and Life Sciences
Child
Child, Preschool
Children
Children & youth
Cognitive ability
Diarrhea
Digestive system
Digestive tract
Drug therapy
Elementary school students
Feces - parasitology
Female
Gastrointestinal diseases
Gastrointestinal Microbiome - drug effects
Gastrointestinal tract
Gastrointestinal tract diseases
Health aspects
Health risks
Helminthiasis
Helminthiasis - drug therapy
Helminthiasis - epidemiology
Humans
Infections
Intestinal flora
Intestinal microflora
Laboratories
Male
Malnutrition
Mass Drug Administration
Mebendazole
Mebendazole - administration & dosage
Mebendazole - therapeutic use
Medical ethics
Medical research
Medicine and Health Sciences
Micro-organisms
Microbiomes
Microbiota
Microbiota (Symbiotic organisms)
Microfauna
Microorganisms
Nematodes
Ova
Parasites
Pediatric research
Preschool children
Risk factors
Software
Soil - parasitology
Song Yang
Statistics
Stunting
Thailand - epidemiology
Trichuris trichiura
Tropical diseases
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Soil-transmitted helminths, such as roundworms (Ascaris lumbricoides), whipworms (Trichuris trichiura) and hookworms (Necator americanus and Ancylostoma spp.), are gastrointestinal parasites that occur predominantly in low- to middle-income countries worldwide and disproportionally impact children. Depending on the STH species, health status of the host and infection intensity, direct impacts of these parasites include malnutrition, anaemia, diarrhoea and physical and cognitive stunting. The indirect consequences of these infections are less well understood. Specifically, gastrointestinal infections may exert acute or chronic impacts on the natural gut microfauna, leading to increased risk of post-infectious gastrointestinal disorders, and reduced gut and overall health through immunomodulating mechanisms. To date a small number of preliminary studies have assessed the impact of helminths on the gut microbiome, but these studies are conflicting. Here, we assessed STH burden in 273 pre-school and school-aged children in Tha Song Yang district, Tak province, Thailand receiving annual oral mebendazole treatment. Ascaris lumbricoides (107/273) and Trichuris trichiura (100/273) were the most prevalent species and often occurred as co-infections (66/273). Ancylostoma ceylanicum was detected in a small number of children as well (n = 3). All of these infections were of low intensity (
ISSN:1935-2735
1935-2727
1935-2735
DOI:10.1371/journal.pntd.0009597