Comparative Y-chromosome analysis among Cypriots in the context of historical events and migrations

• Published in: PloS one 2021-08, Vol.16 (8), p.e0255140-e0255140
• Main Authors: Moutsouri, Irene, Keravnou, Anna, Manoli, Panayiotis, Bertoncini, Stefania, Michailidou, Kyriaki, Christofi, Vasilis, Xenophontos, Stavroulla, Cariolou, Marios A, Bashiardes, Evy
• Format: Article
• Language: English
• Subjects: Biology and Life Sciences; Chromosomes; Chromosomes, Human, Y - genetics; Comparative analysis; Computer and Information Sciences; Cyprus; Engineering and Technology; Genetic analysis; Genetic distance; Genetics; Genetics, Population; Genotypes; Genotyping; Geography; Haplotypes; Haplotypes - genetics; Human Migration; Humans; Immigrants; Laboratories; Medicine; Microsatellite Repeats - genetics; Network analysis; Neurology; People and Places; Polymorphism, Single Nucleotide - genetics; Population; Population genetics; Population studies; Populations; Religion; Severe acute respiratory syndrome coronavirus 2; Short tandem repeats; Single-nucleotide polymorphism; Time Factors; Y chromosome; Y chromosomes
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0255140

Y-chromosome analysis provides valuable information regarding the migration patterns of male ancestors, ranging from the Paleolithic age to the modern humans. STR and SNP genotyping analysis provides data regarding the genetic and geographical ancestry of the populations studied. This study focused on the analysis of the Y-chromosome in Maronite Cypriots and Armenian Cypriots, who came to the island as a result of different historical events. The aim was to provide information on the paternal genetic ancestry of Maronites and Armenians of Cyprus and investigate any affinity with the Greek Cypriots and Turkish Cypriots of the island. Since there is limited information in the current literature, we proceeded and used 23 Y-chromosome STRs and 28 Y-chromosome SNPs to genotype 57 Maronite Cypriots and 56 Armenian Cypriots, which were then compared to data from 344 Greek Cypriots and 380 Turkish Cypriots. All samples were assigned to eight major Y-haplogroups but the most frequent haplogroup among all Cypriots is haplogroup J in the major subclade J2a-L559. The calculated pairwise genetic distances between the populations show that Armenian Cypriots are genetically closer to Greek and Turkish Cypriots compared to Maronite Cypriots. Median Joining Network analysis in 17 Y-STR haplotypes of all Cypriots assigned to J2a-L559, revealed that Cypriots share a common paternal ancestor, prior to the migration of the Armenians and Maronites to Cyprus, estimated in the Late Bronze Age and Early Iron Age.