Association between serum uric acid and cardiovascular disease risk factors in adolescents in America: 2001-2018

SUA is associated with cardiovascular disease and cardiovascular disease risk factors in adults, including chronic kidney disease, coronary artery disease, stroke, diabetes mellitus, preeclampsia, and hypertension. A cross-sectional study was carried out among 11219 adolescents 12 to 18 years of age...

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Bibliographic Details
Published in:PloS one 2021-08, Vol.16 (8), p.e0254590-e0254590
Main Authors: Shi, Qiqi, Wang, Ran, Zhang, Huifeng, Shan, Yaping, Ye, Ming, Jia, Bing
Format: Article
Language:English
Subjects:
Adolescent
Adolescents
Age
Biology and Life Sciences
Blood Pressure
Body mass index
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - blood
Cardiovascular Diseases - genetics
Cardiovascular Diseases - pathology
Child
Child development
Cholesterol
Cholesterol - blood
Cholesterol, HDL - blood
Coronary artery
Coronary artery disease
Creatinine
Diabetes
Diabetes mellitus
Disease control
Ethnicity
Fasting
Female
Females
Genetic Association Studies
Genetic Predisposition to Disease
Glucose
Glucose - metabolism
Health aspects
Health risks
Heart Disease Risk Factors
Heart diseases
Heart surgery
High density lipoprotein
Hispanic people
Humans
Hypertension
Hypertension - blood
Hypertension - genetics
Hypertension - pathology
Insulin
Insulin - blood
Kidney diseases
Low density lipoprotein
Male
Medicine and Health Sciences
Nutrition
Pediatrics
People and Places
Physical Sciences
Pre-eclampsia
Risk analysis
Risk factors
Sex Characteristics
Teenagers
Triglycerides
Uric acid
Uric Acid - blood
Youth
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Summary:SUA is associated with cardiovascular disease and cardiovascular disease risk factors in adults, including chronic kidney disease, coronary artery disease, stroke, diabetes mellitus, preeclampsia, and hypertension. A cross-sectional study was carried out among 11219 adolescents 12 to 18 years of age examined in the 2001-2018 National health and Nutrition Examination Survey. We examined the association between SUA and CVD risk factors. The overall mean SUA level was 5.00±1.24mg/dl. Restricted cubic spline analysis results revealed SUA was inversely associated with HDL-C and SPISE and positively associated with TC, TG, LDL-C, nonHDL-C, insulin, SBP and DBP after full adjustment. Multiple logistic analyses showed SUA level was independently associated with high TC, high TG, high nonHDL-C and low HDL-C (all p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0254590