Impact of radiofrequency ablation (RFA) on bone quality in a murine model of bone metastases

Thermal therapies such as radiofrequency ablation (RFA) are gaining widespread clinical adoption in the local treatment of skeletal metastases. RFA has been shown to successfully destroy tumor cells, yet the impact of RFA on the quality of the surrounding bone has not been well characterized. RFA tr...

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Published in:PloS one 2021-09, Vol.16 (9), p.e0256076-e0256076
Main Authors: Ghomashchi, Soroush, Whyne, Cari M, Chinnery, Tricia, Habach, Fayez, Akens, Margarete K
Format: Article
Language:English
Subjects:
Ablation
Ablation (Surgery)
Age
Animal models
Animals
Backscatter
Backscattering
Biology and Life Sciences
Biomedical materials
Biophysics
Bone cancer
Bone growth
Bone Neoplasms - metabolism
Bone Neoplasms - secondary
Bone Neoplasms - surgery
Calcification, Physiologic
Cancer
Care and treatment
Collagen
Complications and side effects
Design
Disease Models, Animal
Ductility
Electron imaging
Female
General anesthesia
Health care networks
Heat
Histopathology
Homogeneity
Mammary Neoplasms, Experimental - metabolism
Mammary Neoplasms, Experimental - pathology
Mammary Neoplasms, Experimental - surgery
Medicine and Health Sciences
Metastases
Metastasis
Mineralization
Osteogenesis
Osteolysis
Pain
Patient outcomes
Radio frequency
Radiofrequency Ablation
Rats
Rats, Nude
Research and Analysis Methods
Risk assessment
Second harmonic generation
Surgery
Tomography, X-Ray Computed
Treatment Outcome
Tumor cells
Tumors
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cited_by cdi_FETCH-LOGICAL-c593t-cf5759798a9a64e89995a622cdff9f47ca25b060b4912c1a68ec615c8b64b22a3
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description Thermal therapies such as radiofrequency ablation (RFA) are gaining widespread clinical adoption in the local treatment of skeletal metastases. RFA has been shown to successfully destroy tumor cells, yet the impact of RFA on the quality of the surrounding bone has not been well characterized. RFA treatment was performed on femora of rats with bone metastases (osteolytic and osteoblastic) and healthy age matched rats. Histopathology, second harmonic generation imaging and backscatter electron imaging were used to characterize changes in the structure, organic and mineral components of the bone after RFA. RFA treatment was shown to be effective in targeting tumor cells and promoting subsequent new bone formation without impacting the surrounding bone negatively. Mineralization profiles of metastatic models were significantly improved post-RFA treatment with respect to mineral content and homogeneity, suggesting a positive impact of RFA treatment on the quality of cancer involved bone. Evaluating the impact of RFA on bone quality is important in directing the growth of this minimally invasive therapeutic approach with respect to fracture risk assessment, patient selection, and multimodal treatment planning.
doi_str_mv 10.1371/journal.pone.0256076
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identifier ISSN: 1932-6203
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language eng
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source Publicly Available Content (ProQuest); PubMed Central
subjects Ablation
Ablation (Surgery)
Age
Animal models
Animals
Backscatter
Backscattering
Biology and Life Sciences
Biomedical materials
Biophysics
Bone cancer
Bone growth
Bone Neoplasms - metabolism
Bone Neoplasms - secondary
Bone Neoplasms - surgery
Calcification, Physiologic
Cancer
Care and treatment
Collagen
Complications and side effects
Design
Disease Models, Animal
Ductility
Electron imaging
Female
General anesthesia
Health care networks
Heat
Histopathology
Homogeneity
Mammary Neoplasms, Experimental - metabolism
Mammary Neoplasms, Experimental - pathology
Mammary Neoplasms, Experimental - surgery
Medicine and Health Sciences
Metastases
Metastasis
Mineralization
Osteogenesis
Osteolysis
Pain
Patient outcomes
Radio frequency
Radiofrequency Ablation
Rats
Rats, Nude
Research and Analysis Methods
Risk assessment
Second harmonic generation
Surgery
Tomography, X-Ray Computed
Treatment Outcome
Tumor cells
Tumors
title Impact of radiofrequency ablation (RFA) on bone quality in a murine model of bone metastases
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