Update: Gender differences in CABG outcomes—Have we bridged the gap?

Appreciation of unique presentation, patterns and underlying pathophysiology of coronary artery disease in women has driven gender based risk stratification and risk reduction efforts over the last decade. Data regarding whether these advances have resulted in unequivocal improvements in outcomes of...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2021-09, Vol.16 (9), p.e0255170-e0255170
Main Authors: Matyal, Robina, Qureshi, Nada Qaisar, Mufarrih, Syed Hamza, Sharkey, Aidan, Bose, Ruma, Chu, Louis M, Liu, David C, Senthilnathan, Venkatachalam, Mahmood, Feroze, Khabbaz, Kamal R
Format: Article
Language:English
Subjects:
Biology and Life Sciences
Body mass index
Cardiovascular disease
Cardiovascular diseases
Care and treatment
Coronary artery
Coronary artery bypass
Coronary artery disease
Coronary vessels
Critical care
Demographic aspects
Diabetes
Diabetes mellitus
Ejection fraction
Engineering and Technology
Epidemiology
Females
Gender
Gender aspects
Gender differences
Heart attacks
Heart diseases
Heart failure
Heart surgery
Males
Medical schools
Medicine
Medicine and Health Sciences
Men
Morbidity
Mortality
Pain
Patient outcomes
Patients
Postoperative period
Regression analysis
Risk management
Sex differences
Thorax
Variables
Ventilators
Women
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c720t-8195f6334be815f8023e07bde9e15c363c3393a43fe06b188a7a628226699ebd3
cites cdi_FETCH-LOGICAL-c720t-8195f6334be815f8023e07bde9e15c363c3393a43fe06b188a7a628226699ebd3
container_end_page e0255170
container_issue 9
container_start_page e0255170
container_title PloS one
container_volume 16
creator Matyal, Robina
Qureshi, Nada Qaisar
Mufarrih, Syed Hamza
Sharkey, Aidan
Bose, Ruma
Chu, Louis M
Liu, David C
Senthilnathan, Venkatachalam
Mahmood, Feroze
Khabbaz, Kamal R
description Appreciation of unique presentation, patterns and underlying pathophysiology of coronary artery disease in women has driven gender based risk stratification and risk reduction efforts over the last decade. Data regarding whether these advances have resulted in unequivocal improvements in outcomes of CABG in women is conflicting. The objective of our study was to assess gender differences in post-operative outcomes following CABG. Retrospective analyses of institutional data housed in the Society of Thoracic Surgeons (STS) database for patients undergoing CABG between 2002 and 2020 were conducted. Multivariable regression analysis was conducted to investigate gender differences in post-operative outcomes. P-values were adjusted using Bonferroni correction to reduce type-I errors. Our final cohort of 6,250 patients had fewer women than men (1,339 vs. 4,911). more women were diabetic (52.0% vs. 41.2%, p
doi_str_mv 10.1371/journal.pone.0255170
format article
fullrecord <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_2572894645</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A675548252</galeid><doaj_id>oai_doaj_org_article_f31405b573dc41e3a972b6a6a311ece6</doaj_id><sourcerecordid>A675548252</sourcerecordid><originalsourceid>FETCH-LOGICAL-c720t-8195f6334be815f8023e07bde9e15c363c3393a43fe06b188a7a628226699ebd3</originalsourceid><addsrcrecordid>eNqNkt9u0zAUxiMEYmPwBkhEQkJw0WL72E6yC1CpWFdp0iRg3FqOc9K6SuNiJwPueAiekCfBXQNa0C6QL2wd_853_uhLkqeUTClk9PXG9b7VzXTnWpwSJgTNyL3kmBbAJpIRuH_rfZQ8CmFDiIBcyofJEXDBBGVwnJxd7Srd4Wm6wLZCn1a2rtFjazCktk3ns3eL1PWdcVsMv378PNfXmH7FtPS2WmGVdmtMV3r39nHyoNZNwCfDfZJcnb3_ND-fXFwulvPZxcRkjHSTnBailgC8xJyKOicMkGRlhQVSYUCCAShAc6iRyJLmuc60ZDljUhYFlhWcJM8OurvGBTWsICgmMpYXXHIRieWBqJzeqJ23W-2_K6etugk4v1Lad9Y0qGqgnIhSZFAZThF0kbFSaqmBUjQoo9aboVpfbrEy2HZeNyPR8U9r12rlrlXOORBWRIGXg4B3X3oMndraYLBpdIuuv-kbOMTG84g-_we9e7qBWuk4gG1rF-uavaiayUwInjPBIjW9g4qnwq010S-1jfFRwqtRQmQ6_NatdB-CWn788P_s5ecx--IWu0bddOvgmr6zrg1jkB9A410IHuu_S6ZE7e3-Zxtqb3c12B1-A2GV7jE</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2572894645</pqid></control><display><type>article</type><title>Update: Gender differences in CABG outcomes—Have we bridged the gap?</title><source>Open Access: PubMed Central</source><source>Publicly Available Content (ProQuest)</source><creator>Matyal, Robina ; Qureshi, Nada Qaisar ; Mufarrih, Syed Hamza ; Sharkey, Aidan ; Bose, Ruma ; Chu, Louis M ; Liu, David C ; Senthilnathan, Venkatachalam ; Mahmood, Feroze ; Khabbaz, Kamal R</creator><contributor>Deo, Salil</contributor><creatorcontrib>Matyal, Robina ; Qureshi, Nada Qaisar ; Mufarrih, Syed Hamza ; Sharkey, Aidan ; Bose, Ruma ; Chu, Louis M ; Liu, David C ; Senthilnathan, Venkatachalam ; Mahmood, Feroze ; Khabbaz, Kamal R ; Deo, Salil</creatorcontrib><description>Appreciation of unique presentation, patterns and underlying pathophysiology of coronary artery disease in women has driven gender based risk stratification and risk reduction efforts over the last decade. Data regarding whether these advances have resulted in unequivocal improvements in outcomes of CABG in women is conflicting. The objective of our study was to assess gender differences in post-operative outcomes following CABG. Retrospective analyses of institutional data housed in the Society of Thoracic Surgeons (STS) database for patients undergoing CABG between 2002 and 2020 were conducted. Multivariable regression analysis was conducted to investigate gender differences in post-operative outcomes. P-values were adjusted using Bonferroni correction to reduce type-I errors. Our final cohort of 6,250 patients had fewer women than men (1,339 vs. 4,911). more women were diabetic (52.0% vs. 41.2%, p&lt;0.001) and hypertensive (89.1% vs. 84.0%, p48 hours (OR: 1.65 [1.21, 2.45], p = 0.002) and cardiac readmissions (OR: 1.56 [1.27, 2.30], p = 0.003). After adjustment for comorbidity burden, mortality rates in women were comparable to those of age-matched men. The findings of our study indicate that despite apparent reduction of differences in mortality, the burden of postoperative morbidity is still high among women.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0255170</identifier><identifier>PMID: 34525123</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Biology and Life Sciences ; Body mass index ; Cardiovascular disease ; Cardiovascular diseases ; Care and treatment ; Coronary artery ; Coronary artery bypass ; Coronary artery disease ; Coronary vessels ; Critical care ; Demographic aspects ; Diabetes ; Diabetes mellitus ; Ejection fraction ; Engineering and Technology ; Epidemiology ; Females ; Gender ; Gender aspects ; Gender differences ; Heart attacks ; Heart diseases ; Heart failure ; Heart surgery ; Males ; Medical schools ; Medicine ; Medicine and Health Sciences ; Men ; Morbidity ; Mortality ; Pain ; Patient outcomes ; Patients ; Postoperative period ; Regression analysis ; Risk management ; Sex differences ; Thorax ; Variables ; Ventilators ; Women</subject><ispartof>PloS one, 2021-09, Vol.16 (9), p.e0255170-e0255170</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Matyal et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 Matyal et al 2021 Matyal et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c720t-8195f6334be815f8023e07bde9e15c363c3393a43fe06b188a7a628226699ebd3</citedby><cites>FETCH-LOGICAL-c720t-8195f6334be815f8023e07bde9e15c363c3393a43fe06b188a7a628226699ebd3</cites><orcidid>0000-0001-7669-9426</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2572894645/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2572894645?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids></links><search><contributor>Deo, Salil</contributor><creatorcontrib>Matyal, Robina</creatorcontrib><creatorcontrib>Qureshi, Nada Qaisar</creatorcontrib><creatorcontrib>Mufarrih, Syed Hamza</creatorcontrib><creatorcontrib>Sharkey, Aidan</creatorcontrib><creatorcontrib>Bose, Ruma</creatorcontrib><creatorcontrib>Chu, Louis M</creatorcontrib><creatorcontrib>Liu, David C</creatorcontrib><creatorcontrib>Senthilnathan, Venkatachalam</creatorcontrib><creatorcontrib>Mahmood, Feroze</creatorcontrib><creatorcontrib>Khabbaz, Kamal R</creatorcontrib><title>Update: Gender differences in CABG outcomes—Have we bridged the gap?</title><title>PloS one</title><description>Appreciation of unique presentation, patterns and underlying pathophysiology of coronary artery disease in women has driven gender based risk stratification and risk reduction efforts over the last decade. Data regarding whether these advances have resulted in unequivocal improvements in outcomes of CABG in women is conflicting. The objective of our study was to assess gender differences in post-operative outcomes following CABG. Retrospective analyses of institutional data housed in the Society of Thoracic Surgeons (STS) database for patients undergoing CABG between 2002 and 2020 were conducted. Multivariable regression analysis was conducted to investigate gender differences in post-operative outcomes. P-values were adjusted using Bonferroni correction to reduce type-I errors. Our final cohort of 6,250 patients had fewer women than men (1,339 vs. 4,911). more women were diabetic (52.0% vs. 41.2%, p&lt;0.001) and hypertensive (89.1% vs. 84.0%, p48 hours (OR: 1.65 [1.21, 2.45], p = 0.002) and cardiac readmissions (OR: 1.56 [1.27, 2.30], p = 0.003). After adjustment for comorbidity burden, mortality rates in women were comparable to those of age-matched men. The findings of our study indicate that despite apparent reduction of differences in mortality, the burden of postoperative morbidity is still high among women.</description><subject>Biology and Life Sciences</subject><subject>Body mass index</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Care and treatment</subject><subject>Coronary artery</subject><subject>Coronary artery bypass</subject><subject>Coronary artery disease</subject><subject>Coronary vessels</subject><subject>Critical care</subject><subject>Demographic aspects</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Ejection fraction</subject><subject>Engineering and Technology</subject><subject>Epidemiology</subject><subject>Females</subject><subject>Gender</subject><subject>Gender aspects</subject><subject>Gender differences</subject><subject>Heart attacks</subject><subject>Heart diseases</subject><subject>Heart failure</subject><subject>Heart surgery</subject><subject>Males</subject><subject>Medical schools</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Men</subject><subject>Morbidity</subject><subject>Mortality</subject><subject>Pain</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>Postoperative period</subject><subject>Regression analysis</subject><subject>Risk management</subject><subject>Sex differences</subject><subject>Thorax</subject><subject>Variables</subject><subject>Ventilators</subject><subject>Women</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNqNkt9u0zAUxiMEYmPwBkhEQkJw0WL72E6yC1CpWFdp0iRg3FqOc9K6SuNiJwPueAiekCfBXQNa0C6QL2wd_853_uhLkqeUTClk9PXG9b7VzXTnWpwSJgTNyL3kmBbAJpIRuH_rfZQ8CmFDiIBcyofJEXDBBGVwnJxd7Srd4Wm6wLZCn1a2rtFjazCktk3ns3eL1PWdcVsMv378PNfXmH7FtPS2WmGVdmtMV3r39nHyoNZNwCfDfZJcnb3_ND-fXFwulvPZxcRkjHSTnBailgC8xJyKOicMkGRlhQVSYUCCAShAc6iRyJLmuc60ZDljUhYFlhWcJM8OurvGBTWsICgmMpYXXHIRieWBqJzeqJ23W-2_K6etugk4v1Lad9Y0qGqgnIhSZFAZThF0kbFSaqmBUjQoo9aboVpfbrEy2HZeNyPR8U9r12rlrlXOORBWRIGXg4B3X3oMndraYLBpdIuuv-kbOMTG84g-_we9e7qBWuk4gG1rF-uavaiayUwInjPBIjW9g4qnwq010S-1jfFRwqtRQmQ6_NatdB-CWn788P_s5ecx--IWu0bddOvgmr6zrg1jkB9A410IHuu_S6ZE7e3-Zxtqb3c12B1-A2GV7jE</recordid><startdate>20210915</startdate><enddate>20210915</enddate><creator>Matyal, Robina</creator><creator>Qureshi, Nada Qaisar</creator><creator>Mufarrih, Syed Hamza</creator><creator>Sharkey, Aidan</creator><creator>Bose, Ruma</creator><creator>Chu, Louis M</creator><creator>Liu, David C</creator><creator>Senthilnathan, Venkatachalam</creator><creator>Mahmood, Feroze</creator><creator>Khabbaz, Kamal R</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-7669-9426</orcidid></search><sort><creationdate>20210915</creationdate><title>Update: Gender differences in CABG outcomes—Have we bridged the gap?</title><author>Matyal, Robina ; Qureshi, Nada Qaisar ; Mufarrih, Syed Hamza ; Sharkey, Aidan ; Bose, Ruma ; Chu, Louis M ; Liu, David C ; Senthilnathan, Venkatachalam ; Mahmood, Feroze ; Khabbaz, Kamal R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c720t-8195f6334be815f8023e07bde9e15c363c3393a43fe06b188a7a628226699ebd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Biology and Life Sciences</topic><topic>Body mass index</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>Care and treatment</topic><topic>Coronary artery</topic><topic>Coronary artery bypass</topic><topic>Coronary artery disease</topic><topic>Coronary vessels</topic><topic>Critical care</topic><topic>Demographic aspects</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Ejection fraction</topic><topic>Engineering and Technology</topic><topic>Epidemiology</topic><topic>Females</topic><topic>Gender</topic><topic>Gender aspects</topic><topic>Gender differences</topic><topic>Heart attacks</topic><topic>Heart diseases</topic><topic>Heart failure</topic><topic>Heart surgery</topic><topic>Males</topic><topic>Medical schools</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Men</topic><topic>Morbidity</topic><topic>Mortality</topic><topic>Pain</topic><topic>Patient outcomes</topic><topic>Patients</topic><topic>Postoperative period</topic><topic>Regression analysis</topic><topic>Risk management</topic><topic>Sex differences</topic><topic>Thorax</topic><topic>Variables</topic><topic>Ventilators</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Matyal, Robina</creatorcontrib><creatorcontrib>Qureshi, Nada Qaisar</creatorcontrib><creatorcontrib>Mufarrih, Syed Hamza</creatorcontrib><creatorcontrib>Sharkey, Aidan</creatorcontrib><creatorcontrib>Bose, Ruma</creatorcontrib><creatorcontrib>Chu, Louis M</creatorcontrib><creatorcontrib>Liu, David C</creatorcontrib><creatorcontrib>Senthilnathan, Venkatachalam</creatorcontrib><creatorcontrib>Mahmood, Feroze</creatorcontrib><creatorcontrib>Khabbaz, Kamal R</creatorcontrib><collection>CrossRef</collection><collection>Opposing Viewpoints in Context (Gale)</collection><collection>Gale in Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological &amp; Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database (Proquest)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science &amp; Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Advanced Technologies &amp; Aerospace Collection</collection><collection>Agricultural &amp; Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Meteorological &amp; Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>Biological Sciences</collection><collection>Agriculture Science Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>ProQuest Biological Science Journals</collection><collection>Engineering Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>ProQuest advanced technologies &amp; aerospace journals</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matyal, Robina</au><au>Qureshi, Nada Qaisar</au><au>Mufarrih, Syed Hamza</au><au>Sharkey, Aidan</au><au>Bose, Ruma</au><au>Chu, Louis M</au><au>Liu, David C</au><au>Senthilnathan, Venkatachalam</au><au>Mahmood, Feroze</au><au>Khabbaz, Kamal R</au><au>Deo, Salil</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Update: Gender differences in CABG outcomes—Have we bridged the gap?</atitle><jtitle>PloS one</jtitle><date>2021-09-15</date><risdate>2021</risdate><volume>16</volume><issue>9</issue><spage>e0255170</spage><epage>e0255170</epage><pages>e0255170-e0255170</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Appreciation of unique presentation, patterns and underlying pathophysiology of coronary artery disease in women has driven gender based risk stratification and risk reduction efforts over the last decade. Data regarding whether these advances have resulted in unequivocal improvements in outcomes of CABG in women is conflicting. The objective of our study was to assess gender differences in post-operative outcomes following CABG. Retrospective analyses of institutional data housed in the Society of Thoracic Surgeons (STS) database for patients undergoing CABG between 2002 and 2020 were conducted. Multivariable regression analysis was conducted to investigate gender differences in post-operative outcomes. P-values were adjusted using Bonferroni correction to reduce type-I errors. Our final cohort of 6,250 patients had fewer women than men (1,339 vs. 4,911). more women were diabetic (52.0% vs. 41.2%, p&lt;0.001) and hypertensive (89.1% vs. 84.0%, p48 hours (OR: 1.65 [1.21, 2.45], p = 0.002) and cardiac readmissions (OR: 1.56 [1.27, 2.30], p = 0.003). After adjustment for comorbidity burden, mortality rates in women were comparable to those of age-matched men. The findings of our study indicate that despite apparent reduction of differences in mortality, the burden of postoperative morbidity is still high among women.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><pmid>34525123</pmid><doi>10.1371/journal.pone.0255170</doi><tpages>e0255170</tpages><orcidid>https://orcid.org/0000-0001-7669-9426</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1932-6203
ispartof PloS one, 2021-09, Vol.16 (9), p.e0255170-e0255170
issn 1932-6203
1932-6203
language eng
recordid cdi_plos_journals_2572894645
source Open Access: PubMed Central; Publicly Available Content (ProQuest)
subjects Biology and Life Sciences
Body mass index
Cardiovascular disease
Cardiovascular diseases
Care and treatment
Coronary artery
Coronary artery bypass
Coronary artery disease
Coronary vessels
Critical care
Demographic aspects
Diabetes
Diabetes mellitus
Ejection fraction
Engineering and Technology
Epidemiology
Females
Gender
Gender aspects
Gender differences
Heart attacks
Heart diseases
Heart failure
Heart surgery
Males
Medical schools
Medicine
Medicine and Health Sciences
Men
Morbidity
Mortality
Pain
Patient outcomes
Patients
Postoperative period
Regression analysis
Risk management
Sex differences
Thorax
Variables
Ventilators
Women
title Update: Gender differences in CABG outcomes—Have we bridged the gap?
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-21T06%3A07%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Update:%20Gender%20differences%20in%20CABG%20outcomes%E2%80%94Have%20we%20bridged%20the%20gap?&rft.jtitle=PloS%20one&rft.au=Matyal,%20Robina&rft.date=2021-09-15&rft.volume=16&rft.issue=9&rft.spage=e0255170&rft.epage=e0255170&rft.pages=e0255170-e0255170&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0255170&rft_dat=%3Cgale_plos_%3EA675548252%3C/gale_plos_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c720t-8195f6334be815f8023e07bde9e15c363c3393a43fe06b188a7a628226699ebd3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2572894645&rft_id=info:pmid/34525123&rft_galeid=A675548252&rfr_iscdi=true