Dpp and Hedgehog promote the glial response to neuronal apoptosis in the developing Drosophila visual system

Damage in the nervous system induces a stereotypical response that is mediated by glial cells. Here, we use the eye disc of Drosophila melanogaster as a model to explore the mechanisms involved in promoting glial cell response after neuronal cell death induction. We demonstrate that these cells rapi...

Full description

Saved in:
Bibliographic Details
Published in:PLoS biology 2021-08, Vol.19 (8), p.e3001367-e3001367
Main Authors: Velarde, Sergio B, Quevedo, Alvaro, Estella, Carlos, Baonza, Antonio
Format: Article
Language:English
Subjects:
Animal development
Apoptosis
Biology and Life Sciences
c-Jun protein
Cell cycle
Cell death
Cell migration
Cell proliferation
Drosophila
Eye
Fruit flies
Glial cells
Hedgehog protein
Hedgehog proteins
Insects
JNK protein
Kinases
Medicine and Health Sciences
Morphology
Mortality
Nervous system
Neuroglia
Neuronal-glial interactions
Peripheral nervous system
Phagocytes
Photoreceptors
Physiological aspects
Signal transduction
Signaling
Social Sciences
Transcription factors
Visual pathways
Visual system
Zoological research
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Damage in the nervous system induces a stereotypical response that is mediated by glial cells. Here, we use the eye disc of Drosophila melanogaster as a model to explore the mechanisms involved in promoting glial cell response after neuronal cell death induction. We demonstrate that these cells rapidly respond to neuronal apoptosis by increasing in number and undergoing morphological changes, which will ultimately grant them phagocytic abilities. We found that this glial response is controlled by the activity of Decapentaplegic (Dpp) and Hedgehog (Hh) signalling pathways. These pathways are activated after cell death induction, and their functions are necessary to induce glial cell proliferation and migration to the eye discs. The latter of these 2 processes depend on the function of the c-Jun N-terminal kinase (JNK) pathway, which is activated by Dpp signalling. We also present evidence that a similar mechanism controls glial response upon apoptosis induction in the leg discs, suggesting that our results uncover a mechanism that might be involved in controlling glial cells response to neuronal cell death in different regions of the peripheral nervous system (PNS).
ISSN:1545-7885
1544-9173
1545-7885
DOI:10.1371/journal.pbio.3001367