Control of snakebite envenoming: A mathematical modeling study

A mathematical model is designed to assess the impact of some interventional strategies for curtailing the burden of snakebite envenoming in a community. The model is fitted with real data set. Numerical simulations have shown that public health awareness of the susceptible individuals on snakebite...

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Bibliographic Details
Published in:PLoS neglected tropical diseases 2021-08, Vol.15 (8), p.e0009711-e0009711
Main Authors: Abdullahi, Shuaibu Ahijo, Habib, Abdulrazaq Garba, Hussaini, Nafiu
Format: Article
Language:English
Subjects:
Antivenom
Biology and Life Sciences
Bites
Bites and stings
Care and treatment
Control
Cost analysis
Cost effectiveness
Disabilities
Disability
Disease
Epidemiology
Fatalities
Mathematical analysis
Mathematical models
Medical care, Cost of
Medicine and Health Sciences
Mortality
Optimal control
Ordinary differential equations
People and Places
Population
Public health
Rabies
Snake bites
Snakes
Social Sciences
Statistics
Tropical diseases
Venom
Zoonoses
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Summary:A mathematical model is designed to assess the impact of some interventional strategies for curtailing the burden of snakebite envenoming in a community. The model is fitted with real data set. Numerical simulations have shown that public health awareness of the susceptible individuals on snakebite preventive measures could reduce the number of envenoming and prevent deaths and disabilities in the population. The simulations further revealed that if at least fifty percent of snakebite envenoming patients receive early treatment with antivenom a substantial number of deaths will be averted. Furthermore, it is shown using optimal control that combining public health awareness and antivenom treatment averts the highest number of snakebite induced deaths and disability adjusted life years in the study area. To choose the best strategy amidst limited resources in the study area, cost effectiveness analysis in terms of incremental cost effectiveness ratio is performed. It has been established that the control efforts of combining public health awareness of the susceptible individuals and antivenom treatment for victims of snakebite envenoming is the most cost effective strategy. Approximately the sum of US$72,548 is needed to avert 117 deaths or 2,739 disability adjusted life years that are recorded within 21 months in the study area. Thus, the combination of these two control strategies is recommended.
ISSN:1935-2735
1935-2727
1935-2735
DOI:10.1371/journal.pntd.0009711