Factors associated with severe sepsis in diarrheal adults and their outcome at an urban hospital, Bangladesh: A retrospective analysis

To describe factors associated with severe sepsis in diarrheal adults and their outcomes and offender in blood and stool to understand their interplay as clinical features of sepsis and severe diarrhea often overlap. We used this retrospective chart analysis employing an unmatched case-control desig...

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Bibliographic Details
Published in:PloS one 2021-09, Vol.16 (9), p.e0257596-e0257596
Main Authors: Sarmin, Monira, Begum, Monjory, Islam, Farhana, Afroze, Farzana, Shahrin, Lubaba, Sharifuzzaman, Alam, Tahmina, Shahid, Abu Sadat Mohammad Sayeem Bin, Ahmed, Tahmeed, Chisti, Mohammod Jobayer
Format: Article
Language:English
Subjects:
Acidosis
Adults
Antibiotics
Bacteremia
Biology and Life Sciences
Blood
Cardiac arrhythmia
Control charts
Development and progression
Diagnosis
Diarrhea
Gram-negative bacteria
Hypocalcemia
Hypotension
Infections
Injury analysis
Laboratories
Medicine and Health Sciences
Metabolic acidosis
Nutrition
Pathogens
Patients
Physical Sciences
Regression analysis
Risk factors
Sepsis
Septic shock
Steroid hormones
Steroids
Streptococcus infections
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Summary:To describe factors associated with severe sepsis in diarrheal adults and their outcomes and offender in blood and stool to understand their interplay as clinical features of sepsis and severe diarrhea often overlap. We used this retrospective chart analysis employing an unmatched case-control design to study critically ill diarrheal adults aged [greater than or equal to]18 years treated in ICU of Dhaka hospital, icddr,b between January 2011 to December 2015. Of 8,863 in-patient diarrheal adults, 350 having severe sepsis were cases and an equal number of randomly selected non-septic patients were the controls. Cases died significantly more (14.9% vs 4.6%, p =
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0257596