Measles antibody seropositivity among children with allergic diseases: A cross-sectional study in the Japan Environment & Children's Pilot Study

• Published in: PloS one 2021-09, Vol.16 (9), p.e0257721
• Main Authors: Saito-Abe, Mayako, Yamamoto-Hanada, Kiwako, Shoji, Kensuke, Sato, Miori, Irahara, Makoto, Taniguchi, Yu, Sekiyama, Makiko, Mise, Nathan, Ikegami, Akihiko, Shimono, Masayuki, Suga, Reiko, Sanefuji, Masafumi, Ohga, Shouichi, Oda, Masako, Mitsubuchi, Hiroshi, Miyairi, Isao, Ohya, Yukihiro
• Format: Article
• Language: English
• Subjects: Allergic diseases; Allergies; Allergy in children; Antibodies; Antibodies, Viral - blood; Antibodies, Viral - immunology; Asthma; Biology and Life Sciences; Caregivers; Child; Children; Children & youth; Childrens health; Cross-Sectional Studies; Dermatitis; Disease prevention; Drug dosages; Environmental health; Environmental studies; Enzyme immunoassay; Female; Food allergies; Health aspects; Health care; Humans; Hypersensitivity - blood; Hypersensitivity - epidemiology; Hypersensitivity - immunology; IgG antibody; Immune response; Immune system; Immunization; Immunoassay; Immunoglobulin G; Immunoglobulin G - blood; Immunoglobulin G - immunology; Immunoglobulins; Infections; Infectious diseases; Japan - epidemiology; Laboratories; Male; Measles; Measles - epidemiology; Measles - immunology; Measles vaccine; Measles Vaccine - immunology; Measles virus - immunology; Medicine and Health Sciences; Pediatric research; Pediatrics; Physiological aspects; Pilot Projects; Population studies; Preventive medicine; Prospective Studies; Questionnaires; Research and Analysis Methods; Rhinitis; Seroepidemiologic Studies; Serology; Vaccines; Womens health
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0257721

The relationship between allergic individuals and their responsiveness to routine vaccines has rarely been investigated. This study examined whether the seroprevalence of measles antibody differed between children with and without allergic diseases in the general pediatric population. The cross-sectional study was performed within a prospective general birth cohort (a pilot study of the Japan Environment & Children's Pilot Study [JECS]) of children aged 8 years. The clinical history of allergic diseases, measles, and the concentration of measles immunoglobulin G titers in serum enzyme immunoassay were examined. Fisher's exact tests were used to assess the relationships between the allergic characteristics of the children and their measles antibody positivity rates. This study included 162 children. Any allergic disease was reported in 75 (46.3%). The measles antibody positivity rate was 94.7% among children with any allergic diseases and 92.0% among children without allergic diseases. Our results revealed no differences in measles antibody seropositivity between children with allergies and controls. Children with allergies mount and maintain a comparable immune response to the measles vaccine.