Effects of a BMI1008 mixture on postoperative pain in a rat model of incisional pain

The purpose of this study was to evaluate the analgesic effect of BMI1008 (a new drug containing lidocaine, methylene blue, dexamethasone and vitamin B complex) and to investigate the analgesic effect of lidocaine and BMI-L (other components of BMI1008 except lidocaine) at different concentrations i...

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Bibliographic Details
Published in:PloS one 2021-09, Vol.16 (9), p.e0257267-e0257267
Main Authors: Choi, Geun Joo, Ahn, Eun Jin, Lee, Oh Haeng, Kang, Hyun
Format: Article
Language:English
Subjects:
Analgesia - methods
Analgesics
Analgesics - administration & dosage
Anesthesiology
Animals
Behavior, Animal
Care and treatment
Complications and side effects
Dexamethasone
Dexamethasone - administration & dosage
Dose-Response Relationship, Drug
Drugs
Evaluation
Experiments
Fentanyl
Laboratory animals
Lidocaine
Lidocaine - administration & dosage
Male
Medical research
Medical schools
Medicine
Medicine and Health Sciences
Methylene blue
Methylene Blue - administration & dosage
Modelling
Pain
Pain Management - methods
Pain, Postoperative
Pain, Postoperative - prevention & control
Pain, Postoperative - therapy
Patient outcomes
Patient satisfaction
Pharmaceuticals
Physical Sciences
Postoperative period
Rats
Rats, Sprague-Dawley
Research and Analysis Methods
Rodents
Statistical analysis
Surgery
Surgical Wound
Sutures
Vitamin B
Vitamin B Complex - administration & dosage
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Summary:The purpose of this study was to evaluate the analgesic effect of BMI1008 (a new drug containing lidocaine, methylene blue, dexamethasone and vitamin B complex) and to investigate the analgesic effect of lidocaine and BMI-L (other components of BMI1008 except lidocaine) at different concentrations in a rat model of incisional pain. Male Sprague-Dawley rats (250-300 g) were used for the incisional pain model simulating postoperative pain. After the operation, normal saline, various concentrations of BMI1008, lidocaine with a fixed concentration of BMI-L, and BMI-L with a fixed concentration of lidocaine were injected at the incision site. The preventive analgesic effect was evaluated using BMI1008 administered 30 min before and immediately after the operation. In addition, BMI1008 was compared with positive controls using intraperitoneal ketorolac 30 mg/kg and fentanyl 0.5 μg/kg. The mechanical withdrawal threshold was measured with a von Frey filament. The analgesic effect according to the concentration of BMI1008, lidocaine with a fixed concentration of BMI-L, and BMI-L with a fixed concentration of lidocaine showed a concentration-dependent response and statistically significant difference among the groups (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0257267