Catch-up immunization for adolescents and young adults during pre-travel consultation in Japan

• Published in: PloS one 2021-10, Vol.16 (10), p.e0258357-e0258357
• Main Authors: Yamamoto, Kei, Suzuki, Michiyo, Ujiie, Mugen, Kanagawa, Shuzo, Ohmagari, Norio
• Format: Article
• Language: English
• Subjects: Adolescents; Adults; Antibodies; Biology and life sciences; Chicken pox; Children; Disease control; Disease prevention; Drug dosages; Evaluation; Global health; Health aspects; Hospitals; Immunization; Immunosuppressive agents; Infectious diseases; Measles; Medical records; Medicine; Medicine and health sciences; Middle schools; Mumps; People and Places; Public health; Regression analysis; Rubella; Teenagers; Tourism; Travel; Travel industry; Travelers; Vaccination; Vaccines; Varicella; Vector-borne diseases; Yellow fever; Young adults
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0258357

Rubella and measles outbreaks in adults occur because of unimmunized or partially immunized status. Travel clinics play an important role in catch-up measles, rubella, mumps, and varicella immunization for adults. We evaluated the need for catch-up measles, rubella, mumps, and varicella immunization by young adults at our travel clinic. This retrospective observational study was conducted at the National Center for Global Health and Medicine from June 1, 2017 to May 31, 2018. Adults aged 16–49 years who received pre-travel consultation and had childhood immunization records were included. Individuals who fully or partially received planned measles, rubella, mumps, and varicella catch-up immunization were classified as “immunized.” We calculated the proportion of “immunized” individuals and analyzed the factors associated with catch-up measles, rubella, mumps, and varicella immunization at pre-travel consultation using logistic regression analysis. Overall, 3,456 individuals received pre-travel consultations during the study period; 827 (336 men, median age 22 years) had childhood immunization records. The most common trip purposes were study (33%) and tourism (24%). The most common destination was Asia (39%). Catch-up immunization of any measles, rubella, mumps, and varicella vaccine was needed by 755 individuals. After consultation, 20–46% of these participants who needed catchup immunization received at least one dose of immunization. Factors that are negatively associated with measles, rubella, mumps, and varicella catch-up immunization were tourism (odds ratio 0.37 to 0.58), yellow fever vaccination (0.45 to 0.50) (excluding varicella), and each disease history (0.13 to 0.40) (excluding rubella and varicella). Further studies are needed to identify barriers to catch-up immunization.